TABLE 2.

Heterogeneity and sensitivity analyses of MR. Abbreviations: MR, Mendelian randomization analysis; SNPs, Number of single nucleotide polymorphism; GBM, Glioblastoma; IVW, Inverse Variance Weighted; MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier.

Gut microbiota	Outcome	Methods	Q	P	Intercept	P	MR-PRESSO
family.Peptostreptococcaceae	GBM
		IVW	12.152	0.434	0.044	0.735	0.530
		MR-Egger	12.019	0.362
family.Ruminococcaceae	GBM
		IVW	5.115	0.745	0.082	0.670	0.600
		MR-Egger	4.917	0.670
genus.Anaerostipes	GBM
		IVW	8.193	0.770	−0.191	0.338	0.800
		MR-Egger	7.190	0.783
genus.Eubacterium brachy group	GBM
		IVW	8.011	0.533	0.141	0.562	0.850
		MR-Egger	7.645	0.469
genus.Faecalibacterium	GBM
		IVW	7.745	0.560	−0.083	0.586	0.540
		MR-Egger	7.422	0.492
genus.Lachnospiraceae UCG004	GBM
		IVW	8.505	0.668	0.051	0.817	0.720
		MR-Egger	8.448	0.585
genus.Phascolarctobacterium	GBM
		IVW	5.796	0.670	0.207	0.530	0.660
		MR-Egger	5.359	0.616
genus.Prevotella7	GBM
		IVW	5.465	0.858	−0.142	0.683	0.870
		MR-Egger	5.287	0.809
genus.Streptococcus	GBM
		IVW	11.041	0.607	0.207	0.343	0.640
		MR-Egger	10.066	0.610