Table 2.
Association variants identified for all ROP samples with p < 5 × 10-6.
| SNP | Chr | pos | Effect Allele | AF | rsq | OR (95% CI) | p-value | p-value adj for BW & GA | Gene | eQTL p-value |
|---|---|---|---|---|---|---|---|---|---|---|
| rs2058019 | 7 | 42226712 | T | 0.06 | 0.96 | 1.27 (1.17,1.38) | 5.25E-08 | 4.96E-09* | GLI3 | NA |
| rs11563856 | 7 | 90141855 | G | 0.17 | 0.91 | 1.14 (1.09,1.20) | 5.84E-08 | 1.71E-07 | CLDN12 | >0.05 |
| rs62052253 | 16 | 90048889 | T | 0.22 | 0.81 | 1.13 (1.08,1.19) | 9.67E-07 | 4.50E-07 | DEF8, TUBB3 | 0.00027 |
| rs61948265 | 13 | 36559030 | A | 0.14 | 0.68 | 1.14 (1.08,1.20) | 7.90E-06 | 6.50E-07 | DCLK1 | 0.02 |
| rs141411503 | 7 | 21465569 | T | 0.06 | 0.89 | 1.21 (1.12,1.30) | 3.51E-05 | 8.38E-07 | SP4 | 0.015 |
| rs78971944 | 13 | 111811973 | G | 0.09 | 0.87 | 1.17 (1.10,1.24) | 8.70E-06 | 1.83E-06 | ARHGEF7 | >0.05 |
| rs9644892 | 9 | 8800078 | G | 0.37 | 0.93 | 1.10 (1.06,1.14) | 1.40E-06 | 2.14E-06 | PTPRD | 0.0077 |
| rs72870405 | 2 | 162937083 | A | 0.13 | 0.96 | 1.14 (1.08,1.20) | 1.13E-06 | 3.56E-06 | DPP4 | >0.05 |
| rs2306129 | 8 | 99105726 | C | 0.39 | 0.84 | 1.09 (1.05,1.13) | 6.04E-05 | 3.77E-06 | ERICH5, RPL30, RIDA | 1.9e-21 |
| rs7751076 | 6 | 3980472 | A | 0.09 | 0.93 | 1.17 (1.09,1.25) | 9.37E-04 | 5.52E-06 | PRPF4B | >0.05 |
Gene names in bold text indicate a prior association with neovascular retinal disease.