Table 8.
Top-gene RNA-sequencing-based expression in human donor macular retinal or RPE/choroid tissue isolated using the Utah Protocol.
| hg19 position | Gene name | Tissue type with higher expression | Fold change between RPE and retina | P-value |
|---|---|---|---|---|
| chr16:89985572-90002500 | TUBB3 | Neurosensory Retina | 35.201 | 1.03E-130 |
| chr8:99037078-99058697 | RPL30 | RPE | 2.974 | 5.69259E-61 |
| chr13:36345477-36705443 | DCLK1 | Neurosensory Retina | 10.303 | 6.27566E-29 |
| chr7:103112230-103629963 | RELN | Neurosensory Retina | 10.599 | 2.41595E-28 |
| chr7:21467651-21554440 | SP4 | Neurosensory Retina | 2.467 | 2.09322E-23 |
| chr16:90014332-90034468 | DEF8 | Neurosensory Retina | 1.709 | 1.10865E-20 |
| chr7:90013034-90142716 | CLDN12 | Neurosensory Retina | 2.050 | 7.47808E-16 |
| chr7:42000547-42277469 | GLI3 | RPE | 2.454 | 3.30197E-15 |
| chr9:8314245-10612723 | PTPRD | Neurosensory Retina | 3.962 | 5.21447E-13 |
| chr2:162848750-162931052 | DPP4 | RPE | 2.725 | 2.96267E-08 |
| chr13:111766158-111768025 | ARHGEF7 | Neurosensory Retina | 2.276 | 3.91738E-05 |
Differential expression between macular retinal and RPE/Choroid was calculated and p-values corrected for multiple testing using Benjamini–Hockberg. The absolute fold change is represented between the tissue with higher expression versus the tissue with lower expression.