Table 2.
Notable disease-cell type associations
| Disease/trait | Cell type | Data source | τ∗ (SE) | p-value(τ∗) | q-value |
|---|---|---|---|---|---|
| Insomnia75 | Photoreceptor cells | Fetal brain scATAC | 0.81 (0.23) | 4.58 × 10−4 | 2.02 × 10−3 |
| MDD76 | Photoreceptor cells | Fetal brain scATAC | 0.67 (0.17) | 8.45 × 10−5 | 5.26 × 10−4 |
| SCZ77 | Inhibitory neurons | Fetal brain scATAC | 0.98 (0.22) | 6.14 × 10−6 | 7.08 × 10−5 |
| BMI76 | Ganglion cells | Fetal brain scATAC | 0.55 (0.09) | 8.72 × 10−10 | 6.84 × 10−8 |
| Insomnia78 | Purkinje neurons | Fetal brain scATAC | 0.73 (0.21) | 6.01 × 10−4 | 2.48 × 10−3 |
| ADHD79 | Astrocytes | Fetal brain scATAC | 1.05 (0.32) | 9.68 × 10−4 | 3.72 × 10−3 |
| Reaction time45 | Ganglion cells | Fetal brain scRNA | 0.45 (0.14) | 1.26 × 10−3 | 3.93 × 10−2 |
| MDD80 | BDNF excitatory neurons | Adult brain scATAC | 1.31 (0.20) | 1.14 × 10−10 | 4.10 × 10−9 |
| Bipolar disorder81 | Parvalbumin interneurons | Adult brain scATAC | 1.23 (0.28) | 7.35 × 10−6 | 8.23 × 10−5 |
| SCZ77 | VGLUT2 excitatory neurons | Adult brain scATAC | 1.31 (0.24) | 4.14 × 10−8 | 7.45 × 10−7 |
| Intelligence82 | Corticofugal projection neurons | Adult brain scRNA | 0.76 (0.14) | 1.17 × 10−7 | 1.39 × 10−5 |
We report the disease/trait, cell type, data source, standardized effect size (τ∗), p-value for positive τ∗, and FDR q-value for selected results. Full results are reported in Supplementary Data 5, Supplementary Data 7, Supplementary Data 15, Supplementary Data 16. A description of diseases/traits analyzed is provided in Supplementary Data 1. MDD major depressive disorder, SCZ schizophrenia, BMI body mass index, ADHD attention deficit hyperactivity disorder.