Table 1.
Characteristics of the selected studies.
| Author | Year | Country | Cases | Age (Case: Control) | Sex (female/male) | TNM stage |
Lymph node metastasis (Y: N) | Distant metastasis (Y: N) | Studies (n) | Test material | Test method | Index | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Quan-Jun Deng (24) | 2016 | China | GC participants | NA | NA | NA | NA | NA | 25 | Gastric adenocarcinoma tissue and matched normal adjacent tissue | qRT-PCR | ① | 6 |
| Yue Li (25) | 2017 | China | GC participants | <55 (64): ≥56 (86) | 94:56 | I16: II30: III54: IV50 | 118:32 | 50:100 | 150 | GC tissue | qRT-PCR | ①②③④⑤⑥⑦ | 6 |
| Zhengmao Lu (26) | 2019 | China | GC participants | 50.26 ± 12.02: 46.53 ± 11.14 | 39/31(Cases): 37/33(Controls) | NA | NA | NA | 70:70 | Serum | qRT-PCR | ① | 6 |
| Jijun Li (27) | 2017 | China | GC participants | ≤50 (45): > 50 (33) | 42/36 | I+II36: III+IV42 | 35:43 | 28: 50 | 78 | Gastric adenocarcinoma tissue and matched normal adjacent tissue | qRT-PCR | ①②③④⑤⑥⑦ | 7 |
| Na Keum Lee (28) | 2017 | South Korea | GC participants | <65 (24): ≥65 (23) | 32/15 | I+II21: III 26 | 31:16 | NA | 50 | Gastric adenocarcinoma tissue and matched normal adjacent tissue | qRT-PCR | ①②④⑦ | 6 |
| Yoshinaga Okugawa (21) | 2014 | USA | GC participants | <69 (71): ≥69 (79) | 119/31 | NA | 105:45 | 27: 123 | 150 | GC tissue and corresponding noncancerous gastric mucosa | qRT-PCR | ①④⑥⑦ | 6 |
| Kongxi Zhu (29) | 2019 | China | GC participants | 42 ± 13.1 | 30/34 | NA | NA | 37: 27 | 64 | Blood sample | RT-qPCR | ①⑤⑥ | 8 |
| Guoyi Shao (30) | 2020 | China | GC participants |
56.3 (37-72) | 39/18 | NA | NA | NA | 57 | GC tissue and corresponding noncancerous adjacent tissue | RT-qPCR | ① | 7 |
| Di Chen (31) | 2017 | China | GC participants |
NA | NA | NA | NA | NA | 20 | GC and adjacent normal mucosa | qRT-PCR | ① | 6 |
| Hongwei Xia (32) | 2016 | China | GC participants |
NA | NA | NA | NA | 25: 14 | 39 | Gastric adenocarcinoma tissue and matched normal adjacent tissue | Q-PCR | ①⑥ | 7 |
| Vahid Chaleshi (33) | 2021 | Iran | GC participants |
60.32 ± 14.185 | 34/7 | I4: III22: IV15 | 4:34 | NA | 41 | Gastric adenocarcinoma tissue and matched normal adjacent tissue | qRT-PCR | ① | 7 |
| Yue Zhang (34) | 2017 | China | GC participants |
≤60 (40): > 60 (20) | 38/22 | 39:21 | NA | 60 | GC tissue and adjacent normal tissue | qRT-PCR | ①②③④⑦ | 7 | |
| Farbod Esfandi (35) | 2020 | Iran | GC participants |
42.53 (14–55) | 22/6 | I1: II9: III13: IV6 | 24:5 | 24: 5 | 30 | Gastric cancer tissue and adjacent normal tissue | qRT-PCR | ① | 7 |
| Xiaoning Li (36) | 2022 | China | GC participants |
59 ± 10 | 24/13 | I12: II4: III14: IV7 | 28:9 | 4: 33 | 37 | GC tissue and adjacent normal tissue | qRT-PCR | ① | 7 |
① Expression level. ② The effect of high/low MALAT1 expression on stage. ③ The effect of high/low MALAT1 expression on the histologic grade. ④ The effect of high/low MALAT1 expression on lymph node metastasis. ⑤ The effect of high/low MALAT1 expression on distant metastasis. ⑥ The effect of high/low MALAT1 expression on survival. ⑦ The effect of high/low MALAT1 expression on the T stage. NA, Not Available.