Table 3.
Associations between neuropsychological measurements and incident Alzheimer’s disease dementia in individuals with amnestic mild cognitive impairment
| Variable | Hazard ratio | Lower 95%CI | Upper 95%CI | p-value |
|---|---|---|---|---|
| Sex | 0.93 | 0.77 | 1.52 | .424 |
| Episodic memory | 0.88 | 0.86 | 0.89 | < .001 |
| Sex by episodic memory | 0.99 | 0.96 | 1.01 | .343 |
| Sex | 2.22 | 1.23 | 3.98 | .008 |
| Naming | 0.95 | 0.93 | 0.96 | < .001 |
| Sex by naming | 0.97 | 0.95 | 0.99 | .007 |
| Sex | 0.89 | 0.59 | 1.35 | .587 |
| Verbal fluency | 0.94 | 0.93 | 0.95 | < .001 |
| Sex by verbal fluency | 1.00 | 0.98 | 1.01 | .851 |
| Sex | 1.82 | 1.01 | 3.29 | .048 |
| Attention | 0.95 | 0.92 | 0.99 | .011 |
| Sex by attention | 0.94 | 0.89 | 0.99 | .027 |
| Sex | 0.80 | 0.63 | 0.99 | .047 |
| Processing speed | 1.010 | 1.007 | 1.013 | < .001 |
| Sex by processing speed | 1.004 | 0.999 | 1.008 | .113 |
| Sex | 0.80 | 0.64 | 1.00 | .052 |
| Executive function | 1.005 | 1.004 | 1.006 | < .001 |
| Sex by executive function | 1.001 | 1.000 | 1.003 | .048 |
Models were adjusted for age, education, BMI, race, history of PD, B12 deficiency or DM and reported use of antidepressants or anxiolytic/sedative/hypnotic agents. First the main effects of sex (female sex was used as the reference category) and neuropsychological measurements are provided and then sex by neuropsychological measurements interactions are quoted (female sex by neuropsychological measurements interactions was used as the reference category).