Table 1.
Effect of wild-type CFTR transfection on intracellularpH (pHi) recovery in CFPAC cells
| pHi Recovery Rate, pH units/min | Percent Inhibition, Matched Pairs | ||
|---|---|---|---|
| Cell Type | No CPX | 50 nM CPX | |
| CFPAC-1 | 0.144 ± 0.039 (16) | 0.096 ± 0.020 (9) | 38.5 ± 1.5 (9) |
| CFPAC-PLJ-6 | 0.207 ± 0.046 (8) | 0.090 ± 0.025 (8) | 54.4 ± 8.3 (8) |
| CFPAC-PLJ-4.7 | 0.097 ± 0.013 (9) | 0.081 ± 0.013 (9) | 10.9 ± 2.5 (9) |
Recovery rates measured in presence or 50 nM 8-cycloen-tyl-1,3-dipropylxanthine (CPX) are given as means ± SE (n, number of experiments given in parentheses). Inhibition by 50 nM CPX of recovery rates in matched pairs (as % of control on same cell) is given in last column. Means of %inhibition values of CFPAC-1 and of CFPAC-PLJ-6 cells are each significantly different (at 0.005 level) from means of CFPAC-PLJ-4.7 cells, whereas they are not significantlv different from each other.