Table 1. Baseline Clinical Characteristics of the Study Population by Clonal Hematopoiesis Risk Score Risk Group.
| Characteristic | Presence of CHIP/CCUS | CHIP/CCUS risk group | |||||
|---|---|---|---|---|---|---|---|
| No (n = 2933) | Yes (n = 938) | P value | Low (n = 562) | Intermediate (n = 318) | High (n = 58) | P value | |
| Age, mean (SD), y | 75.31 (5.06) | 76.86 (5.41) | <.001 | 76.22 (5.25) | 77.65 (5.57) | 78.76 (5.18) | <.001 |
| Sex | |||||||
| Male | 1172 (40.0) | 435 (46.4) | .001 | 239 (42.5) | 165 (51.9) | 31 (53.4) | <.001 |
| Female | 1761 (60.0) | 503 (53.6) | 323 (57.5) | 153 (48.1) | 27 (46.6) | ||
| Race | |||||||
| Black | 674 (23.0) | 221 (23.6) | .75 | 111 (19.8) | 96 (30.2) | 14 (24.1) | .006 |
| White | 2259 (77.0) | 717 (76.4) | 451 (80.2) | 222 (69.8) | 44 (75.9) | ||
| Center | |||||||
| Forsyth County, North Carolina | 526 (17.9) | 178 (19.0) | .89 | 111 (19.8) | 58 (18.2) | 9 (15.5) | .007 |
| Jackson, Mississippi | 631 (21.5) | 202 (21.5) | 100 (17.8) | 89 (28.0) | 13 (22.4) | ||
| Minneapolis, Minnesota | 1061 (36.2) | 337 (35.9) | 219 (39.0) | 99 (31.1) | 19 (32.8) | ||
| Washington County, Maryland | 715 (24.4) | 221 (23.6) | 132 (23.5) | 72 (22.6) | 17 (29.3) | ||
| Body mass index, mean (SD)a | 28.85 (5.69) | 28.53 (5.84) | .14 | 28.40 (5.36) | 28.98 (6.60) | 27.30 (5.65) | .07 |
| Diabetes | 931 (32.7) | 286 (31.7) | .63 | 169 (31.2) | 98 (32.3) | 19 (33.9) | .92 |
| Hypertension | 2124 (73.4) | 717 (77.7) | .01 | 419 (75.6) | 255 (81.5) | 43 (76.8) | .02 |
| Smoking | |||||||
| Current | 169 (5.9) | 50 (5.5) | .01 | 33 (6.1) | 15 (4.9) | 2 (3.5) | .12 |
| Former | 1344 (47.1) | 473 (52.3) | 278 (51.3) | 163 (53.3) | 32 (56.1) | ||
| Never | 1126 (39.4) | 305 (33.7) | 188 (34.7) | 101 (33.0) | 16 (28.1) | ||
| Unknown | 216 (7.6) | 77 (8.5) | 43 (7.9) | 27 (8.8) | 7 (12.3) | ||
| History of coronary artery disease | 422 (14.4) | 158 (16.8) | .08 | 85 (15.1) | 64 (20.1) | 9 (15.5) | .06 |
| History of stroke | 109 (3.8) | 38 (4.2) | .69 | 18 (3.3) | 19 (6.1) | 1 (1.8) | .15 |
| History of heart failure | 263 (9.1) | 82 (8.9) | .90 | 36 (6.5) | 39 (12.5) | 7 (12.3) | .02 |
| History of solid cancer | 508 (17.3) | 174 (18.6) | .42 | 100 (17.8) | 63 (19.8) | 11 (19.0) | .73 |
| Follow-up, median (IQR), y | 7.18 (5.67-7.82) | 6.91 (5.42-7.68) | <.001 | 7.10 (5.74-7.76) | 6.44 (5.27-7.55) | 5.54 (3.58-7.35) | <.001 |
Abbreviations: CCUS, clonal cytopenia of undetermined significance; CHIP, clonal hematopoiesis of indeterminate potential.
a
Body mass index is calculated as weight in kilograms divided by height in meters squared.