Table 1.
This table demonstrates the relative change (linear fold change in differential expression) for all treatment cohorts as compared to control for genes that are significantly affected by mNPH and/or radiation and discussed in the text.
| Gene | mNPH | 15 Gy | 3 × 8 Gy | 15 Gy mNPH | 3 × 8 Gy mNPH | Protein & pathway/function |
|---|---|---|---|---|---|---|
|
| ||||||
| ITGAL | 4.03* (1.4) | 9.08* (1.4) | 7.8* (1.4) | 8.98* (1.4) | 5.62* (1.4) | Integrin alpha L (CD11a) – natural killer cell mediated cytotoxicity, activating receptor |
| ITGB2 | 3.18* (1.3) | 6.38* (1.3) | 6.03* (1.2) | 7.02* (1.3) | 5.22* (1.3) | Integrin beta chain-2 (CD18) – natural killer cell mediated cytotoxicity, activating receptor |
| CD94/(klrd1) | 6.03* (1.5) | 24.9* (1.4) | 14.9* (1.4) | 21.9* (1.4) | 7.89* (1.5) | Killer cell lectin-like receptor D1(CD94) – natural killer cell mediated cytotoxicity, inhibitory receptor |
| NKG2D/(klrk1) | 10* (1.5) | 27.5* (1.5) | 26.6* (1.4) | 22* (1.5) | 14.7* (1.5) | Killer cell lectin-like receptor k1 (NKG2D) – natural killer cell mediated cytotoxicity, activating receptor |
| ICOS | 9.72* (1.7) | 30.5* (1.6) | 22.2* (1.6) | 21.8* (1.7) | 16.2* (1.7) | Inducible T-cell costimulator (CD278) – T cell receptor signaling pathway, activating receptor |
| FAS | 3.05* (1.3) | 3.95* (1.3) | 6.43* (1.3) | 4.17* (1.3) | 4.48* (1.3) | FAS – apoptosis pathway, death receptor (activating) |
| Bim | 2.31* (1.2) | 3.68* (1.2) | 2.96* (1.2) | 4.2* (1.2) | 2.71* (1.2) | Bim (Bcl-2-like protein 11) – apoptosis pathway, apoptosis activator |
| NOXA | 4.14* (1.5) | 8.94* (1.5) | 9.45* (1.4) | 9* (1.5) | 9.68* (1.5) | Noxa – apoptosis pathway (Bcl2 family), pro-apoptosis |
| GZMB | 9.87* (1.5) | 29.4* (1.5) | 31.5* (1.5) | 24.7* (1.5) | 18.6* (1.6) | Granzyme B – T-cell mediated apoptosis (and some Natural killer cell mediated), apoptosis inducer |
| Gadd45 | 1.58* (1.2) | 2.38* (1.2) | 2.6* (1.2) | 2.05* (1.2) | 2.79* (1.2) | Gadd45 – DNA Damage pathway, pro-survival/anti-apoptosis |
| PD-1 | 16.5* (1.8) | 34* (1.8) | 26.5* (1.7) | 25.2* (1.8) | 8.64* (1.8) | Programmed Cell Death 1 – T cell receptor signaling, inhibitory/immune regulatory |
| CTLA4 | 1.76 (1.3) | 5.16* (1.3) | 4.51* (1.3) | 3.92* (1.3) | 1.96* (1.4) | Cytotoxic T-lymphocyte-associated protein 4 – T cell receptor signaling, inhibitory/immune regulatory |
| NCR1 | 1.6 (1.8) | 29.2* (1.6) | 36.5* (1.6) | 53.6* (1.6) | 22.5* (1.7) | Natural cytotoxicity triggering receptor 1 (CD335) – natural killer cell mediated cytotoxicity, activating receptor |
Average fold change with standard error are reported.
*
p < .05.