. 2024 Jan 2;9(2):2314–2324. doi: 10.1021/acsomega.3c06225

Table 4. In Vitro Enzyme Inhibitory Activity of the Synthesized Compound on the Triple Mutant EGFR and the Number of Structural Descriptors Contained in the Compound^a.

compound	EGFR^{L858R/T790M/C797S} IC₅₀ (μM)	EGFR^{Del19/T790M/C797S}IC₅₀ (μM)	fr_aniline	NumAromaticHeterocycles
4a	1.221 ± 0.031	1.432 ± 0.022	1	1
4b	0.736 ± 0.044	0.220 ± 0.002	1	1
4c	0.277 ± 0.028	0.089 ± 0.004	1	1
Angew-2017	Nd^b	0.018	1	2

The data are the mean ± SD of at least three independent experiments.

Nd: no data.

Table 4. In Vitro Enzyme Inhibitory Activity of the Synthesized Compound on the Triple Mutant EGFR and the Number of Structural Descriptors Contained in the Compounda.