Table 2. Max Data Upload, Software, Web Server, and Variation Types of Ten Coding Frameshift Small Indels Predictors.

tool	max data uploada	software availa	webserver availa	type of variations
PROVEAN	web-based version has been retired	YES	NO	SNV, insertions and deletions (<6AA)
SIFT Indel	<100 raw	YES	YES	Insertions and deletions (<5 bp)
CADD	<2 MB	YES	YES	SNV, insertions and deletions (<50 bp)
DDIG-IN	Multiple Variations	NO	YES	NFS/FS indels, nonsense, nonymous
VEST-Indel	100–1000000 variations	NO	YES	In-frame, frameshift
MutPred-LOF	<100 variations	YES	YES	Frameshift stop-loss
PredCID	<500 indels	YES	YES	Insertions and deletions
SPD_Pred	N.M.	NO	YES	Single point deletions
PROFOUND	N.A.	YES	N.A.	deletions
MutationTaster2021	One sample in VCF file	N.A.	YES	noncoding variants, short insertions and deletions (<40 bp), frameshift, premature stop codons

^aNote: Software avail: Software availability; Webserver avail: Webserver availability; YES: the corresponding tool has software or Web server; N.A., not applicable; N.M., not mentioned.