Table 2.
Interferon-related pathways negatively enriched in SN-mel-exposed pDCs resulting from the Gene Set Enrichment Analysis (GSEA).
| Unstimulated | Stimulated with R848 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SN-mel 146-exposed pDCs | SN-mel 336-exposed pDCs | SN-mel 146-exposed pDCs | SN-mel 336-exposed pDCs | |||||||||
| ENRICHED PATHWAY | ES | NES | FDR q-val | ES | NES | FDR q-val | ES | NES | FDR q-val | ES | NES | FDR q-val |
| KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY | -0,58 | -2,13 | 0 | -0,58 | -1,53 | 0,24 | -0,48 | -1,83 | 0,01 | -0,61 | -2,49 | 0 |
| REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | -0,66 | -2,37 | 0 | -0,76 | -2,56 | 0 | -0,60 | -2,38 | 0 | -0,75 | -3,21 | 0 |
| REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | -0,65 | -1,99 | 0 | -0,58 | -1,71 | 0,03 | -0,66 | -2,22 | 0 | -0,73 | -2,64 | 0 |
| REACTOME_REGULATION_OF_IFNA_SIGNALING | -0,65 | -1,97 | 0 | -0,60 | -1,68 | 0,04 | -0,76 | -2,49 | 0 | -0,78 | -2,61 | 0 |
| REACTOME_INTERFERON_SIGNALING | -0.43 | -1,80 | 0,01 | -0,54 | -2,03 | 0 | -0,32 | -1,49 | 0,11 | -0,46 | -2,20 | 0 |
| REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS | -0,44 | -1,65 | 0,05 | -0,47 | -1,60 | 0,07 | -0,41 | -1,66 | 0,04 | -0,55 | -2,42 | 0 |
| GO_RESPONSE_TO_TYPE_I_INTERFERON | -0,63 | -2,36 | 0 | -0,73 | -2,41 | 0 | -0,56 | -2,16 | 0 | -0,73 | -3,15 | 0 |
| GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY | -0,59 | -1,99 | 0,03 | -0,55 | -1,73 | 0,18 | -0,64 | -2,30 | 0 | -0,66 | -2,52 | 0 |