Table 3.
Upstream regulators in SN-mel-exposed pDCs predicted to be inhibited or activated based on IPA analysis.
| UPSTREAM REGULATORS | SN-mel 146-exposed pDCs | SN-mel 336-exposed pDCs | ||
|---|---|---|---|---|
| Activation z-score | p-value of overlap | Activation z-score | p-value of overlap | |
| BTK | 3,031 | 6,41E-11 | 4,201 | 1,33E-24 |
| IL1RN | 3,326 | 8,37E-06 | 5,009 | 1,64E-21 |
| TAB1 | 3,317 | 6,9E-0,3 | 2,137 | 2,67E-10 |
| MAPK1 | 3,263 | 1,84E-06 | 5,939 | 2,26E-21 |
| MAPK2K3 | -2 | 2,25E-03 | -2,236 | 6,07E-06 |
| MAPK2K6 | -2 | 1,20E-03 | -2,229 | 2,36E-06 |
| IFNB1 | -2,113 | 1,44E-03 | -3,349 | 2,38E-12 |
| IFNAR2 | -2,236 | 6,9E-0,3 | -2,236 | 3,59E-0,4 |
| NONO | -2,236 | 6,92E-03 | -2 | 3,56E-03 |
| IL27 | -2,335 | 8,01E-10 | -2,132 | 5,70E-10 |
| TLR7 | -2,388 | 1,92E-10 | -2,687 | 2,55E-25 |
| TICAM1 | -2,449 | 1,63E-04 | -2,236 | 7,47E-05 |
| PRL | -2,457 | 1,75E-05 | -5,992 | 1,73E-39 |
| IRF3 | -2,694 | 6,32E-06 | -2,54 | 3,27E-08 |
| TBK1 | -2,774 | 1,55E-06 | -2,219 | 1,17E-04 |
| PDLIM2 | -2,837 | 5,84E-06 | -2,84 | 3,47E-06 |
| IRF7 | -2,951 | 4,80E-06 | -2,798 | 1,66E-07 |
| STAT1 | -3,285 | 1,20E-11 | -4,277 | 2,44E-25 |
| Interferon alpha | -3,385 | 2,11E-12 | -5,094 | 2,50E-44 |
| IRF1 | -3,575 | 1,07E-11 | -2,621 | 8,24E-08 |
| PAF1 | -3,606 | 7,57E-05 | -4,243 | 2,42E-13 |
| NFkB (complex) | -3,645 | 1,17E-14 | -2,043 | 4,44E-09 |
| IFNA2 | -4,038 | 8,37E-06 | -5,868 | 5,22E-33 |
| IFNL1 | -4,124 | 3,47E-09 | -6,27 | 3,68E-41 |
| TLR9 | -4,14 | 1,01E-10 | -4,798 | 2,71E-24 |
| IFNG | -4,2 | 4,9E-18 | -4,856 | 3,69E-36 |
| TNF | -4,342 | 1,08E-23 | -2,167 | 7,50E-16 |