Table 3.
Applicability and compliance with early de-escalation and discontinuation strategies
| Pre-intervention period (n = 87) | Intervention period (n = 103) | |
|---|---|---|
| Episodes when strategies applicable, n (%) | 49 (56) | 71 (69) |
| Compliance*, n (%) | 4 (8) | 55 (77) |
| De-escalation | 4 (8) | 12 (17) |
| De-escalation followed by discontinuation | 0 (0) | 6 (8) |
| Discontinuation | 0 (0) | 37 (52) |
| Non-compliance*, n (%) | 45 (92) | 16 (23) |
| Lack of timelinessa | 2 (4) | 11 (16) |
| Continuation | 40 (82) | 3 (4) |
| Escalation | 3 (6) | 2 (3) |
| Episodes when strategies not applicable, n (%) | 38 (44) | 32 (31) |
*p < 0.001 for the comparison of compliance between pre-intervention and intervention periods
aLack of timeliness was defined as a delay of more than 48 h in the application of early discontinuation or de-escalation strategies