Table 2.
Clinical information of 24 NSCLC-to-SCLC transformation cases identified in this study
| Group/Case | Sex/Age | Smoking | Clinical Stage | Initial pathology | Initial mutation | Treatment Before transformation | Time of TKI treatment before transformation | Re-biopsy specimen | Repeat mutation | Further exome sequencing |
|---|---|---|---|---|---|---|---|---|---|---|
| EGFR-mut/Case 1 | F/59 | Never | IV | LUAD | EGFR-19DEL | Chemo/TKI | 10 months | Lung lesion | EGFR-19DEL | No |
| EGFR-mut/Case 2 | F/50 | Never | IV | LUAD | EGFR-19DEL | Chemo/TKI | 12 months | Supraclavicular lymph nodes | EGFR-19DEL | No |
| EGFR-mut/Case 3 | F/70 | Never | IIIb | LUAD | EGFR-L858R | TKI | 7 months | Lung lesion | EGFR-L858R | No |
| EGFR-mut/Case 4 | M/50 | Never | IV | LUAD | EGFR-L858R | Chemo/TKI | 25 months | Lung lesion | EGFR-L858R/T790M | No |
| EGFR-mut/Case 5 | F/66 | Never | IV | LUAD | EGFR-19DEL | TKI | 17 months | Supraclavicular lymph nodes | EGFR-19DEL | No |
| EGFR-mut/Case 6 | M/63 | Ever | IIIb | LUAD | EGFR-19DEL | TKI | 23 months | Supraclavicular lymph nodes | EGFR-19DEL | No |
| EGFR-mut/Case 7 | F/70 | Never | IV | LUAD | EGFR-19DEL | TKI | 16 months | Lung lesion | EGFR-19DEL | Yes |
| EGFR-mut/Case 8 | F/56 | Never | IIa | LUAD/operated | EGFR-19DEL | Surgical resection | / | Lung lesion | EGFR-19DEL | No |
| EGFR-mut/Case 9 | M/82 | Never | IIIa | LUAD/operated | EGFR-L858R | Surgical resection + TKI | 24 months | Lung lesion | EGFR-L858R | No |
| EGFR-mut/Case 10 | M/59 | Never | IIa | LUAD/operated | EGFR-19DEL | Surgical resection | / | Lumbar metastases | EGFR-19DEL | No |
| EGFR-mut/Case 11 | F/59 | Never | IIa | LUAD/operated | EGFR-19DEL | Surgical resection | / | Lung lesion | EGFR-19DEL | Yes |
| EGFR-mut/Case 12 | F/62 | Never | IIb | LUAD/operated | EGFR-19DEL | Surgical resection + TKI | 22months | Lung lesion | EGFR-19DEL | Yes |
| EGFR-mut/Case 13 | M/69 | Never | IIb | LUAD/operated | EGFR-G719C/S768I | Surgical resection | / | Lung lesion | EGFR-G719C/S768I | Yes |
| EGFR-wt/Case 14 | F/44 | Never | IV | LUAD | ALK rearrangement | Chemo | / | Lung lesion | Wt | No |
| EGFR-wt/Case 15 | M/70 | Never | IIIb | LUAD | ALK rearrangement | Chemo | / | Lung lesion | ALK rearrangement | Yes |
| EGFR-wt/Case 16 | M/55 | Never | IV | LUAD | Wt | Chemo | / | Lung lesion | Wt | No |
| EGFR-wt/Case 17 | F/79 | Ever | IIIb | LUAD | Wt | Chemo | / | Lung lesion | / | No |
| EGFR-wt/Case 18 | F/68 | Never | II | LUAD/operated | Wt | Surgical resection | / | Lung lesion | / | No |
| EGFR-wt/Case 19 | M/64 | Never | IIa | LUAD/operated | Wt | Surgical resection | / | Lung lesion | Wt | Yes |
| EGFR-wt/Case 20 | M/60 | Never | IIIa | LUAD/operated | Wt | Surgical resection | / | Lung lesion | Wt | Yes |
| EGFR-wt/Case 21 | M/51 | Never | IIb | LUAD/operated | Wt | Surgical resection | / | Lung lesion | Wt | Yes |
| EGFR-wt/Case 22 | M/65 | Ever | IIIa | LUSC/operated | Wt | Surgical resection | / | Mediastinal lymph node | / | No |
| EGFR-wt/Case 23 | M/72 | Ever | IIIa | LUSC/operated | Wt | Surgical resection | / | Lung lesion | / | No |
| EGFR-wt/Case 24 | M/74 | Ever | II | LUSC/operated | Wt | Surgical resection | / | Lung lesion | / | No |