Table 2. Kinetic Parameters of the Formation of 17 From Active Thiol 2 and Prodrug 8.
| incubated compound | Vmax [nmol/min/mL blood] | Km [μM] | intrinsic clearance [mL/min/mL blood] |
|---|---|---|---|
| 2 | 5.56 ± 0.09 | 6.05 ± 0.40 | 0.92 |
| 8 | 9.96 ± 0.14 | 15.3 ± 0.85 | 0.65 |
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