Table 3. Pharmacokinetic Parameters of 8, 2, and 17 After Administration of 8 in SD Rats^a.

	5 mg/kg IV			300 mg/kg PO
PK parameter	8	2	17	8	2	17
AUC0–inf [ng*h/mL]	499 ± 30.4	509 ± 36.6	1070 ± 36.06	577 ± 116	9560b	13,700b
AUC0–t [ng*h/mL]	493 ± 31.5	502 ± 34.9	1052 ± 41.74	513 ± 119	8023 ± 991	12,330 ± 3001
t1/2 [h]	0.14 ± 0.02	0.35 ± 0.02	0.84 ± 0.18	1.54 ± 0.28	3.66b	3.03b
tmax [h]		0.08	0.25	0.25	0.25	2.0 ± 1.0
Cmax [ng/mL]		1180 ± 37.86	640 ± 48.7	219 ± 39.4	2950 ± 241	1290 ± 86.6
C0 [ng/mL]	3537 ± 231
CL [mL/min/kg]	169 ± 8.41
MRTinf [h]	0.13 ± 0.01	0.36 ± 0.03	1.2 ± 0.2	2.85 ± 0.86	4.41b	5.76b
Vdss	1.3 ± 0.1
F [%]					31.4b

^aEach value in the table is the mean of three experiments (n = 3), error is reported as SEM.

^bSEM values were not calculated since AUC extrapolated was greater than 25% in one subject.