Table 2.

Results of the applied analysis comparing GIANT and UKB weight GWASs. GIANT = the 2013 Genetic Investigation of ANthropometric Traits consortia GWAS [28]. UKB = Ben Ellsworth UK Biobank GWASs [15]. GWS = genome wide significant (p < 5 × 10^− 8)

GWAS 1	GWAS 2	p-value of meta-analysed difference between the 11 GWS GIANT SNPs		Interpretation
		Fixed effects	Fisher’s method
GIANT weight (Kg)	UKB weight (Kg)	0.130	0.387	Since these are similar phenotypes in simpler populations, we should not, and do not, observe a difference in effect between the two GWASs
	UKB weight (SD)	< 0.001	< 0.001	When the GWASs are measured using different scales, we can misleadingly detect a difference between them
	UKB birthweight (Kg)	< 0.001	< 0.001	Variant-weight associations are known to change with age. As expected, we therefore observe a difference in associations between adult weight and birthweight