Table 2. Demographic, clinical, and functional characteristics in 362 patients with asthma and with normal FEV1 and FEV1/FVC values.
| Total (N = 362) |
Impaired FEF25–75
(N = 71; 19.6%) |
Normal FEF25–75
(N = 291; 80.4%) |
Univariate p-value |
Multivariate (with FEV1) OR (95% CI; p-value) |
Multivariate (with FVC) OR (95% CI; p-value) |
||
|---|---|---|---|---|---|---|---|
| FEF25–75 (% of predicted) | 83.7 ± 22.89 | 54.2 ± 8.60 | 90.9 ± 9.19 | ||||
| Age | 38.2 ± 16.44 | 45.8 ± 15.32 | 36.3 ± 16.19 | < 0.001 | 1.04 (1.02 – 1.06); 0.001 | 1.02 (1.00 – 1.04); 0.018 | |
| Sex | Females | 222 (61.3%) | 49 (69.0%) | 173 (59.5%) | 0.18 | ||
| Males | 140 (38.7%) | 22 (31.0%) | 118 (40.5%) | ||||
| Rhinitis diagnosis | 316 (87.3%) | 61 (85.9%) | 255 (87.6%) | 0.85 | |||
| FVC (% of predicted) | 105.1 ± 14.34 | 102.5 ± 15.32 | 105.7 ± 14.05 | 0.024 | 0.96 (0.93 – 0.98); < 0.001 | ||
| FEV1 (% of predicted) | 100.7 ± 12.15 | 92.5 ± 10.70 | 102.7 ± 11.65 | < 0.001 | 0.91 (0.88 – 0.94); < 0.001 | ||
| FEV1/FVC | 0.82 ± 0.07 | 0.77 ± 0.06 | 0.83 ± 0.07 | < 0.001 | 0.85 (0.80 – 0.90); < 0.001 | 0.81 (0.76 – 0.86); < 0.001 | |
| Asthma symptoms | 216 (59.8%) | 49 (70.0%) | 167 (57.4%) | 0.07 | 2.19 (1.10 – 4.36); 0.026 | 2.32 (1.21 – 4.42); 0.011 | |
| Rhinitis symptoms | 183 (51.0%) | 37 (53.6%) | 146 (50.3%) | 0.72 | |||
| Asthma signs at examination | 18 (5.1%) | 4 (5.9%) | 14 (4.9%) | 0.97 | |||
| Asthma control (GINA criteria) |
Uncontrolled | 28 (7.9%) | 8 (11.4%) | 20 (7.0%) | 0.011 | ||
| Poorly controlled | 134 (37.6%) | 35 (50.0%) | 99 (34.6%) | ||||
| Controlled | 194 (54.5%) | 27 (38.6%) | 167 (58.4%) | ||||
| ACT | 20.4 ± 4.19 | 20.0 ± 4.56 | 20.5 ± 4.10 | 0.51 | |||
FEF25–75 = forced expiratory flow between 25 and 75% of vital capacity. FVC = forced vital capacity. FEV1 = forced expiratory volume in one second. ACT = asthma control test. Data are expressed as mean ± standard deviation.