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. 2024 Jan 17;65(1):29. doi: 10.1167/iovs.65.1.29

Figure 5.

Figure 5.

AZD8797 alleviates the morphology retinal in RD mice model at P28. (A) OCT examination showed that the retina of the RD + AZD8797 group had intact structures and clear boundary between layers. The retinal thickness in the RD + AZD8797 group was significantly larger compared with the RD group. Fundus photography showed that the scale of retinal lesions reduced significantly after AZD8797 treatment. (B) H&E staining showed that the ONL thickness of the RD + AZD8797 group increased significantly compared with the RD group. (C) Immunostaining of rhodopsin showed that the rod photoreceptor in the RD + AZD8797 group had longer IS/OS compared with that of the RD group. (*P < 0.05, **P < 0.01, and ****P < 0.0001, for differences compared with the normal control, and #P < 0.05, ##P < 0.01, ###P < 0.001, and ####P < 0.0001, for differences between animal groups, n = 6).