The synthesis of AMFFs from AcMF using FCRa.
| ||||
|---|---|---|---|---|
| Entry | Product code | Product(s) | Yield (%) | |
| 1 | 1a |
|
59b | |
| 2 | 1b |
|
|
76c |
| 3 | 1c |
|
82 | |
| 4 | 1d |
|
|
77c |
| 5 | 1e |
|
|
76c |
| 6 | 1f |
|
81 | |
| 7 | 1g |
|
|
79c |
| 8 | 1h |
|
|
75c |
Reaction conditions: AcMF (0.502 g, 2.98 mmol), arene (4 equiv., 11.94 mmol), ZnCl2 (0.250 g, 50 wt%), 120 °C, 3 h.
A round-bottomed ACE glass pressure vessel was used.
Combined yield of ortho- and para-isomer.