Table 1.
Comparison of analytical methods reported in the literature for SARS-CoV-2 detection
| Sensor | Technique | Target | LOD | Time (min) | Reference |
|---|---|---|---|---|---|
| BC/G-PEG/ACE2/BSA/Nafion | potentiometry | SP | 4.26 × 10−18 g mL−1 and 0.05 copies μL−1 |
10 | This study |
| GA/ACE2/BSA/Nafion | IES | SP | 2.80 × 10−15 g mL−1 | 4 | 43 |
| Paper/GO/SARS-CoV-2 antibody | SWV | IgG and IgM | 0.96 and 0.14 × 10−9 g mL−1 | 30 | 59 |
| Cotton-tipped electrode/SARS-CoV-2 antibody | SWV | N protein | 8.01 × 10−13 g mL−1 | 21 | 60 |
| GPE/GA/AuNP-cys/ACE2/BSA | SWV | SP | 1.96 × 10−13 g mL−1 | 6.5 | 4 |
| Graphene-ssDNA-AuNP/Au electrode | chronopotentiometry | N gene | 6.92 copies μL−1 | 5 | 61 |
| SARS-CoV-2 RapidFlex | DPV and OCP-EIS | viral antigen nucleo-capsid protein | 0.50 × 10−15 g mL−1 | 10 | 62 |
| AuNPs/CPP/AFB1 | colorimetric | SARS-CoV-2 RNA | 200 copies μL−1 | 5 | 63 |
| Cotton swab/AuNPs/ACE2 | colorimetric | SP | 0.15 × 10−12 g mL−1 | 5 | 3 |
| DETECTR | CRISPR technology | E gene and N gene | 10 copies μL−1 | 40 | 64 |
| AuNP/ASOs | colorimetric | N gene | 0.18 × 10−9 g mL−1 | 30 | 65 |
SWV, square wave voltammetry; DPV, differential pulse voltammetry; GPE, graphite pencil electrode; GA, glutaraldehyde; AuNPs, gold nanoparticles; cys, cysteamine; CPP, cationic perylene probe; AFB1, aptasensor for rapid detection of aflatoxin B1; ASOs, antisense oligonucleotides specific for N gene.