Table 2:

Associations between glomerular clusters and time-to-event outcomes from Cox models, unadjusted and adjusted for demographics, clinical characteristics, and disease diagnosis.

A. Complete remission of proteinuria
	Unadjusted		Adjusted for demographics + clinical characteristics a		Adjusted for disease diagnosis + demographics + clinical characteristics a
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Glomerular Clusters		<0.001		0.01		0.3
X (reference)
Y	1.82 (1.03, 3.23)	0.04	1.95 (0.99, 3.85)	0.05	1.60 (0.80, 3.18)	0.2
Z	3.10 (1.79, 5.37)	<.001	3.29 (1.52, 7.13)	0.003	2.02 (0.86, 4.74)	0.1
B. Composite of ≥40% decline in eGFR with eGFR < 90 or ESRD
	Unadjusted		Adjusted for selected demographics + clinical characteristics a		Adjusted for disease diagnosis + selected demographics + clinical characteristics b
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Glomerular Clusters		<0.001		<0.001		0.002
X (reference)
Y	0.19 (0.08, 0.45)	<0.001	0.22 (0.08, 0.57)	0.002	0.22 (0.09, 0.54)	<0.001
Z	0.06 (0.02, 0.20)	<.001	0.11 (0.03, 0.45)	0.002	0.29 (0.07, 1.12)	0.07

^aAdjusted for demographics (patient age, sex, black race, Hispanic ethnicity) + clinical characteristics included patient age, sex, black race, Hispanic ethnicity, eGFR and UPCR at biopsy, kidney disease duration as of biopsy and immunosuppressant use at biopsy. Additional adjustment for disease diagnosis included MCD/MCD-Like vs. FSGS.

Due to a limited number of events of the composite outcome, adjustment covariates were selected based on backward elimination:

^aadjusted demographics + clinical characteristics included kidney disease duration as of biopsy, and eGFR and UPCR at biopsy;

^badjusted demographics + clinical characteristics included kidney disease duration as of biopsy and UPCR at biopsy. Additional adjustment for disease diagnosis included MCD/MCD-Like vs. FSGS.