Table 3.
Meta-analysis for Bcl-2, MMP-2, MMP-9, caspase-3, and CyclinD1 (in vitro studies).
| Experimental |
Control |
Std. Mean Difference | ||||||
|---|---|---|---|---|---|---|---|---|
| Study or Subgroup | Mean | SD | Total | Mean | SD | Total | IV. Random. 95% Cl | P value |
| Bcl-2 | ||||||||
| Baicalein | ||||||||
| Cui, 2008 | 32.21 | 3.35 | 3 | 59.26 | 4.45 | 3 | −5.70 [–11.43, 0.03] | _ |
| Subtotal (95% Cl) | −5.70 [–11.43, 0.03] | p = 0.05 | ||||||
| Wogonin | ||||||||
| Liu, 2016-H | 0.32 | 0.02 | 3 | 0.99 | 0.03 | 3 | −21.02 [–41.39, −0.66] | _ |
| Liu, 2016-L | 0.88 | 0.02 | 3 | 0.99 | 0.03 | 3 | −3.45 [–7.15, 0.25] | _ |
| Liu, 2016-M | 0.67 | 0.01 | 3 | 0.99 | 0.03 | 3 | −11.45 [–22.62, −0.28] | _ |
| Subtotal (95% Cl) I2 = 54% |
−4.73 [–8.18, −1.27] | p = 0.007 | ||||||
| Total (95% Cl) I2 = 32% |
−4.99 [–7.95, −2.02] | p = 0.001 | ||||||
| MMP-2 | ||||||||
| Baicalein | ||||||||
| Chiu, 2011 | 0.58 | 0.25 | 3 | 0.99 | 0.12 | 3 | −1.67 [–3.95, 0.60] | _ |
| Subtotal (95% Cl) | −1.67 [–3.95, 0.60] | p = 0.15 | ||||||
| S. baicalensis | ||||||||
| Park, 2014-H | 0.13 | 0.11 | 3 | 0.79 | 0.01 | 3 | −6.76 [–13.48, −0.04] | _ |
| Park, 2014-L | 0.42 | 0.13 | 3 | 0.79 | 0.01 | 3 | −3.21 [–6.70, 0.28] | _ |
| Subtotal (95% Cl) I2 = 0% |
−3.96 [–7.06, −0.87] | p = 0.01 | ||||||
| Wogonin | ||||||||
| Liu, 2016-H | 0.08 | 0.01 | 3 | 0.99 | 0.01 | 3 | −72.80 [–143.11, −2.49] | _ |
| Liu, 2016-L | 0.38 | 0.01 | 3 | 0.99 | 0.01 | 3 | −48.80 [–95.95, −1.65] | _ |
| Liu, 2016-M | 0.34 | 0.02 | 3 | 0.99 | 0.01 | 3 | −32.89 [–64.68, −1.09] | _ |
| Subtotal (95% Cl) I2 = 0% |
−42.17 [–66.85, −17.48] | p = 0.0008 | ||||||
| Total (95% Cl) I2 = 62% |
−2.69 [–4.52, −0.87] | p = 0.004 | ||||||
| MMP-9 | ||||||||
| Baicalein | ||||||||
| Chiu, 2011 | 0.37 | 0.13 | 3 | 0.99 | 0.12 | 3 | −3.96 [–8.11, 0.18] | _ |
| Subtotal (95% Cl) | −3.96 [–8.11, 0.18] | p = 0.06 | ||||||
| Baicalin | ||||||||
| Xiao, 2012-H | 21.85 | 3.41 | 3 | 41.48 | 3.55 | 3 | −4.51 [–9.15, 0.13] | _ |
| Xiao, 2012-L | 33.26 | 4.07 | 3 | 41.48 | 3.55 | 3 | −1.72 [–4.03, 0.59] | _ |
| Subtotal (95% Cl) I2 = 10% |
−2.27 [–4.34, −0.21] | p = 0.03 | ||||||
| Total (95% Cl) I2 = 0% |
−2.61 [–4.46, −0.76] | p = 0.006 | ||||||
| Caspase-3 | ||||||||
| Baicalein | ||||||||
| Kuo, 2009 | 0.79 | 0.05 | 3 | 0.19 | 0.03 | 3 | 0.60 [0.53, 0.67] | _ |
| Liang, 2012-H | 3.55 | 0.19 | 3 | 0.99 | 0.01 | 3 | 2.56 [2.34, 2.78] | _ |
| Liang, 2012-L | 1.5 | 0.42 | 3 | 0.99 | 0.01 | 3 | 0.51 [0.03, 0.99] | _ |
| Liang, 2012-M | 2.91 | 0.52 | 3 | 0.99 | 0.01 | 3 | 1.92 [1.33, 2.51] | _ |
| Total (95% Cl) I2 = 99% |
1.40 [0.18, 2.61] | p = 0.02 | ||||||
| CyclinD1 | ||||||||
| Baicalein | ||||||||
| Zheng, 2014-H | 0.33 | 0.07 | 3 | 1 | 0.01 | 3 | −0.67 [–0.75, −0.59] | |
| Zheng, 2014-L | 0.21 | 0.1 | 3 | 1 | 0.01 | 3 | −0.79 [–0.90, −0.68] | |
| Subtotal (95% Cl) I2 = 65% |
−0.72 [–0.84, −0.61] | p < 0.00001 | ||||||
| Wogonin | ||||||||
| Hong, 2020-H | 3.99 | 0.64 | 3 | 1.01 | 0.13 | 3 | 2.98 [2.24, 3.72] | _ |
| Hong, 2020-L | 2.3 | 0.4 | 3 | 1.01 | 0.13 | 3 | 1.29 [0.81, 1.77] | _ |
| Liu, 2016-H | 0.28 | 0.01 | 3 | 1 | 0.01 | 3 | −0.72 [–0.74, −0.70] | _ |
| Liu, 2016-L | 0.47 | 0.02 | 3 | 1 | 0.01 | 3 | −0.53 [–0.56, −0.50] | _ |
| Liu, 2016-M | 0.67 | 0.01 | 3 | 1 | 0.01 | 3 | −0.33 [–0.35, −0.31] | _ |
| Subtotal (95% Cl) I2 = 100% |
−0.02 [–0.27, 0.22] | p = 0.84 | ||||||
| Total (95% Cl) I2 = 100% |
−0.27 [–0.46, −0.07] | p = 0.007 | ||||||