Figure 10. Identification of genes responsive to vitamin D status after ACL reconstruction.

(A) Comparison of change in PDK4 transcript counts in vastus lateralis of the injured limb in participants above and below the 30 ng/mL vitamin D status cutoff point (n = 10). (B) PDK4 transcript fold change in vehicle- and 1,25(OH)₂D3-treated human primary myocytes (n = 4 per group). (C) Coding sequence for PDK4 is shown in blue below the VDR red peaks. Rectangles are exons and arrows along the introns indicate direction of mRNA transcription. Multiple splice isoforms are shown. Adjusted P values presented in A and B.