Table 3.
Threshold effect analysis of NLR and other inflammatory markers on DKD, albuminuria, and low-eGFR using a two-piecewise linear regression model in Model 3.
| DKD | Albuminuria | Low-eGFR | ||||
|---|---|---|---|---|---|---|
| OR1 (95%CI2) | P- value | OR (95%CI) | P- value | OR (95%CI) | P- value | |
| NLR | ||||||
| Fitting by standard linear model | 2.90 (1.51, 5.58) | 0.0014 | 2.01 (1.10, 3.68) | 0.0224 | 2.50 (1.05, 5.99) | 0.0390 |
| Fitting by two-piecewise linear model | ||||||
| Breakpoint (K) | 3.43 | 3.22 | 1.88 | |||
| OR1(< K) | 4.30 (1.77, 10.48) | 0.0013 | 3.28 (1.30, 8.31) | 0.0121 | 0.27 (0.04, 1.73) | 0.1685 |
| OR2(> K) | 0.88 (0.14, 5.74) | 0.8961 | 0.60 (0.10, 3.71) | 0.5863 | 24.02 (2.72, 212.30) | 0.0042 |
| OR2/OR1 | 0.21 (0.02, 2.08) | 0.1799 | 0.18 (0.02, 1.98) | 0.1631 | 88.13 (2.72, 285.20) | 0.0116 |
| Logarithmic likelihood ratio test P-value | 0.162 | 0.136 | 0.003 | |||
| MLR | ||||||
| Fitting by standard linear model | 6.93 (2.37, 20.31) | 0.0004 | 5.75 (1.76, 18.76) | 0.0038 | 2.99 (0.76, 11.83) | 0.1177 |
| Fitting by two-piecewise linear model | ||||||
| Breakpoint (K) | 0.43 | 0.29 | 0.21 | |||
| OR1(< K) | 28.87 (6.52, 127.78) | <0.0001 | 55.20 (3.81, 799.07) | 0.0033 | 72.06 (0.60, 455.06) | 0.0747 |
| OR2(> K) | 0.22 (0.01, 4.60) | 0.3281 | 1.47 (0.21, 10.20) | 0.6974 | 1.34 (0.22, 8.33) | 0.7512 |
| OR2/OR1 | 0.01 (0.01, 0.34) | 0.0115 | 0.03 (0.01, 1.25) | 0.0647 | 0.01 (0.01, 5.49) | 0.1468 |
| Logarithmic likelihood ratio test P-value | 0.006 | 0.060 | 0.138 | |||
| PLR | ||||||
| Fitting by standard linear model | 1.01 (0.99, 1.02) | 0.2460 | 1.01 (0.99, 1.03) | 0.1251 | 1.01 (0.99, 1.02) | 0.4864 |
| Fitting by two-piecewise linear model | ||||||
| Breakpoint (K) | 113.64 | 193.57 | 66.14 | |||
| OR1(< K) | 1.03 (0.99, 1.06) | 0.0770 | 1.00 (0.99, 1.02) | 0.7448 | 14.14 (0.01, 52.10) | 0.7752 |
| OR2(> K) | 1.00 (0.98, 1.01) | 0.6753 | 1.06 (1.00, 1.12) | 0.0337 | 0.99 (0.98, 1.01) | 0.5739 |
| OR2/OR1 | 0.97 (0.93, 1.01) | 0.1409 | 1.06 (0.99, 1.13) | 0.0714 | 0.01 (0.01, 2.74) | 0.7750 |
| Logarithmic likelihood ratio test P-value | 0.129 | 0.058 | 0.003 | |||
| SII | ||||||
| Fitting by standard linear model | 1.00 (1.00, 1.01) | 0.0426 | 1.00 (0.99, 1.00) | 0.1171 | 1.00 (0.99, 1.01) | 0.0925 |
| Fitting by two-piecewise linear model | ||||||
| Breakpoint (K) | 149.52 | 850 | 245 | |||
| OR1(< K) | 0.97 (0.92, 1.02) | 0.2072 | 1.00 (0.99, 1.01) | 0.1983 | 0.98 (0.96, 1.00) | 0.0597 |
| OR2(> K) | 1.00 (1.00, 1.01) | 0.0218 | 1.00 (0.99, 1.01) | 0.7228 | 1.00 (1.00, 1.01) | 0.0213 |
| OR2/OR1 | 1.04 (0.98, 1.09) | 0.1844 | 1.00 (0.98, 1.00) | 0.6001 | 1.03 (1.00, 1.05) | 0.0389 |
| Logarithmic likelihood ratio test P-value | 0.182 | 0.599 | 0.031 | |||
| SIRI | ||||||
| Fitting by standard linear model | 3.01 (1.18, 7.68) | 0.0213 | 2.45 (0.92, 6.57) | 0.0742 | 2.17 (0.61, 7.77) | 0.2320 |
| Fitting by two-piecewise linear model | ||||||
| Breakpoint (K) | 1.96 | 1.03 | 0.87 | |||
| OR1(< K) | 4.88 (1.34, 17.81) | 0.0165 | 17.66 (1.09, 286.46) | 0.0434 | 0.02 (0.01, 2.56) | 0.1176 |
| OR2(> K) | 0.68 (0.04, 12.59) | 0.7940 | 0.97 (0.20, 4.68) | 0.9721 | 12.02 (1.27, 113.42) | 0.0299 |
| OR2/OR1 | 0.14 (0.01, 5.03) | 0.2811 | 0.06 (0.01, 2.38) | 0.1312 | 94.21 (0.91, 374.26) | 0.0537 |
| Logarithmic likelihood ratio test P-value | 0.265 | 0.121 | 0.039 | |||
| AISI | ||||||
| Fitting by standard linear model | 1.00 (0.99, 1.01) | 0.1370 | 1.00 (0.99, 1.01) | 0.1744 | 1.00 (0.99, 1.01) | 0.3983 |
| Fitting by two-piecewise linear model | ||||||
| Breakpoint (K) | 252.08 | 143.92 | 264.44 | |||
| OR1(< K) | 1.00 (0.99, 1.00) | 0.3813 | 0.99 (0.97, 1.02) | 0.5628 | 0.99 (0.98, 1.00) | 0.1627 |
| OR2(> K) | 1.00 (1.00, 1.01) | 0.0427 | 1.00 (1.00, 1.01) | 0.1238 | 1.01 (1.00, 1.01) | 0.0572 |
| OR2/OR1 | 1.01 (0.99, 1.02) | 0.1642 | 1.01 (0.98, 1.04) | 0.4599 | 1.01 (1.00, 1.03) | 0.0810 |
| Logarithmic likelihood ratio test P-value | 0.156 | 0.460 | 0.070 | |||
Adjusted for sex, age, race, education level, BMI, smoking status, alcohol consumption, TC, LDL-C, HDL-C, AST, ALT, triglycerides, PIR, CVD, hypertension, fasting glucose, glycohemoglobin, insulin use, diabetes drug use, and marital status.
1OR: Odd ratio.
295% CI: 95% confidence interval.