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. Author manuscript; available in PMC: 2024 Jan 18.
Published in final edited form as: Mater Today (Kidlington). 2022 Dec 8;62:33–50. doi: 10.1016/j.mattod.2022.11.008

FIG. 3. PGEM treatment led to enhanced expression of immunosuppressive chemokines via activating STING signaling pathway.

FIG. 3

(a) Volcano plot showing genes differentially expressed in Panc02 tumors after various treatments; (b) Heat map of chemokines (CCL2, CCL7, and ISG15) expression after various treatments; (c-e) The mRNA expression levels of CCL2 (C), CCL7 (d), and ISG15 (e) in mouse Panc02 tumors treated with saline, GEM, and PGEM for three times; (f-h) The mRNA expression levels of CCL2 (f), CCL7 (g), and ISG15 (h) in cultured Panc02 cell lines treated with saline, GEM, and PGEM; (i) Knock down of STING protein in Panc02 cells assessed by Western blotting after treatments with control siRNA (siNC) or siSTING for 24 h or 48 h; (j) The mRNA expression levels of CCL2, CCL7 and ISG15 after treatments with PGEM plus either siNC or siSTING; (k) The mRNA expression levels of CCL2, CCL7 and ISG15 after treatments with PGEM plus either isotype control or IFNAR1 antibody.