Table 6. Summary of findings: Physical case isolation until all lesions are fully healed versus no physical case isolation until all lesions are fully healed for reducing mpox infection.

Population: Adults and children with confirmed mpox Intervention: Mpox patient does not physically isolatea, covers all non-healed lesions, wears a medical mask Comparator: Mpox patient physically isolateda until all lesions are fully healed Setting: Household and community settings
Outcome	Study results and measurements	Absolute effect estimates transmission		Certainty of evidence	Comment
		Mpox patient isolated until all lesions are fully healed	Mpox patient does not isolate when all non-healed lesions are covered and wears a medical mask
Mpox infection inferred from transmission route frequency datab	2366/4309 cases Direct physical sexual contact 6/4309 cases Direct physical non-sexual contact 2/4309 cases Fomite Inferred odds ratioc: 1	Uncertaind	Uncertaine	Low to Moderatef Due to serious indirectness	Isolating patients probably does not prevent transmission of mpox compared to not isolating patients (provided all lesions are covered, a medical mask is worn and physical contact with others is avoided)

^aPhysical isolation is defined as physical separation from other people.

^bNo studies identified that directly informed the research question; data from route of transmission frequency resulting in mpox infection was inferred.

^c Review findings indicated that mpox was transmitted in almost all occasions by direct physical contact; there were very few cases of fomite transmission. The review team inferred that if all lesions were covered, direct physical contact with others is avoided, and a medical mask worn, there would be no difference between the intervention and comparator groups.

^dWe could not estimate the baseline transmission risk due to absence of data.

^eWe could not estimate the risk in the intervention group due to an unknown baseline risk in the comparator group

^f Rated down one level for indirectness due to limited data on route of transmission frequency for Clade I mpox virus.