Table 2.
Cytotoxicity of the PSMA SMOL-TTC multimers and PSMA expression levels in various prostate cancer cell lines
| Cell line | LNCaP | C4-2 | MDA-PCa-2b | VCaP | 22Rv1 | PC-3 |
|---|---|---|---|---|---|---|
| PSMA antibodies bound/cella | 160,000 | 171,000 | 77,000 | 22.000 | 2000 | 0 |
| PSMA SMOL conjugate | Cytotoxicity(IC50,kBq/mL) | |||||
| [227Th]PSMA-617 | 0.04 | 0.19 | 0.013 | 0.42 | 0.71 | 4.5 |
| [227Th]PSMA-hydroxyethyl-HOPO | 0.67 | 2.14 | N/A | 3.07 | 1.06 | N/A |
| [227Th]D-Glu-PSMA-617 | 0.60 | 3.18 | 0.315 | 4.74 | 1.28 | 7.1 |
| PSMA SMOL-TTC, monomer | 0.02 | 0.17 | 0.012 | 0.97 | 1.28 | 10.2 |
| PSMA SMOL-TTC, dimer | 0.02 | 0.46 | 0.011 | 1.25 | 1.36 | 9.9 |
| PSMA SMOL-TTC, trimer | 0.03 | 1.55 | 0.013 | 1.96 | 1.34 | 11.2 |
| PSMA SMOL-TTC, tetramer | 0.02 | 0.28 | N/A | 1.55 | 1.25 | N/A |