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. 2024 Jan 5;14:1297107. doi: 10.3389/fimmu.2023.1297107

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Copyright © 2024 Yang, Wang, Ye, Xu, Cheng, Sun, Dong, Kong, Zhao, Geng and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal tissue staining of 6 dual antigen-positive IMN patients at our center. From left to right, there are PASM+MASSON staining (×400), IgG immunofluorescence staining (×200), IgG1 immunofluorescence staining (×200), IgG2 immunofluorescence staining (×200), IgG3 immunofluorescence staining (×200), IgG4 immunofluorescence staining (×200), Electron microscope (×12000), PLA2R immunohistochemistry staining (×400), NELL-1 immunohistochemistry staining (×400), THSD7A immunohistochemistry staining in renal tissue. Among the 6 cases,MN1– MN3 are positive for PLA2R and NELL-1 staining; MN4-MN6 are positive for PLA2R and THSD7A staining.