Table 3.
Comparison of clinical and pathologic data between all dual antigen-positive IMN patients and PLA2R single-positive IMN patients at our center.
| Characteristics | IMN with dual antigen positivity(n=17) |
IMN with PLA2R single positivity(n=141) |
P-value |
|---|---|---|---|
| Male(%) | 15 (88.2) | 91 (64.5) | 0.050 |
| Age(year) | 50.0 (40.5, 68.0) | 53.0 (44.3, 63.0) | 0.910 |
| Hypertension(%) (n=152) | 6 (54.5) | 80 (56.7) | 1.000 |
| Diabetes(%) (n=147) | 2 (28.6) | 22 (15.7) | 0.708 |
| 24h-urinary protein(g/24h) | 4.9 (3.4, 5.5) | 4.9 (3.0, 8.3) | 0.510 |
| ALB(g/L) | 24.8 (20.4, 29.1) | 25.9 (22.1, 32.1) | 0.404 |
| Scr(μmol/L) | 71.6 (55.0, 99.9) | 68.0 (57.1, 79.1) | 0.439 |
| eGFR(mL/(min·1.73 m2)) | 106.6 (94.5, 152.5) | 102.3 (86.7, 116.0) | 0.340 |
| Pathological stage(n=151) | 0.264 | ||
| I | 3 (25.0) | 35 (26.0) | |
| II | 9 (75.0) | 75 (55.5) | |
| III | 0 | 25 (18.5) | |
| Crescent body(%)(n=152) | 0 | 4 (2.8) | 1.000 |
| Renal interstitial injury grading(n=151) | 0.257 | ||
| 0 | 3 (27.3) | 16 (11.4) | |
| 1 | 8 (72.7) | 97 (69.3) | |
| 2 | 0 | 24 (17.1) | |
| 3 | 0 | 3 (2.1) | |
| IgG positive(%)(n=153) | 12 (100) | 140 (99.3) | 1.000 |
| IgG1 positive(%)(n=151) | 7 (58.3) | 31 (22.3) | 0.016 |
| IgG2 positive(n=149) | 0 | 8 (5.8) | 1.000 |
| IgG3 positive(%)(n=148) | 0 | 9 (6.5) | 1.000 |
| IgG4 positive(%)(n=152) | 12 (92.3) | 117 (84.2) | 0.705 |
| Simultaneous positivity of IgG1 and IgG4 (%) | 6 (50.0) | 29 (20.9) | 0.053 |
| IgM positive(%)(n=152) | 0 | 17 (12.1) | 0.468 |
| IgA positive(%)(n=153) | 1 (8.3) | 21 (14.9) | 0.847 |
| C3 positive(%)(n=153) | 6 (50) | 108 (76.6) | 0.092 |
| C1q positive(%)(n=152) | 0 | 4 (2.8) | 1.000 |
ALB, serum albumin; Scr, serum creatinine; eGFR, estimated glomerular filtration rate.