Table 2.
Longitudinal laboratory parameters and HIV reservoir measurements in HIV+ participants.
| Value | T0 | DVL | UD | UD+1 |
|---|---|---|---|---|
| CD4 T cells (/µL) | 428 [326-595] | 712 [566-979]** | 818.05 [621.75-930.75]*** | 746 [602.5-931]*** |
| CD8 T cells (/µL) | 774.9 [321-1434.9] | 686 [484-1055.9] | 627 [502.38-867.25] | 581 [473-730.5] |
| CD4/CD8 ratio | 0.52 [0.36-0.86] | 1.02 [0.77-1.46]* | 1.07 [0.8-1.57]*** | 1.25 [0.98-1.8]*** |
| B cells (/µL) | 84.6 [62-125] | 201 [144-226]* | 206 [174-284]*** | 184 [165-244]*** |
| NK cells (/µL) | 186 [146-263.7] | 246 [175-351.1] | 235 [145.8-358.5] | 248 [172-361.5] |
| Monocytes (103/µL) | 0.44 [0.35-0.61] | 0.52 [0.44-0.71] | 0.51 [0.43-0.63] | 0.53 [0.46-0.6] |
| Neutrophils (103/µL) | 2.57 [1.92-3.37] | 3.23 [2.09-4.08] | 3.2 [2.19-3.96] | 3.13 [2.3-4.09] |
| Thrombocytes (103/µL) | 198 [163-262.5] | 238 [221-273.75] | 235 [208.5-281] | 235 [217.25-287] |
| AST (U/L) | 30 [22.5-49.5] | 22 [20-27]* | 22 [18-25] | 22.5 [20.25-25.75]* |
| Plasma viral load (log10 copies/mL) | 6.51 [5.67-7] | 2.2 [1.87-2.43]*** | <50*** | <50*** |
| Total HIV DNA (copies/106 CD4 T cells) | 16574.77 [5095.11-47742.3] | NA | 310.05 [148.61-679.54]*** | 114.25 [50.56-212.62]*** |
| Intact HIV DNA (copies/106 CD4 T cells) | 6039.27 [2883.2-11662.87] | NA | 212.29 [66.33-473.6]* | 36.05 [14.81-82.64]*** |
Data are represented as median [IQR] values. Values which differed significantly from the measurements at the T0 timepoint are indicated with *, p<0.05; **, p<0.01; ***, p<0.001 and marked in bold. P-values were calculated with Friedman’s test and post-hoc Dunn’s test. AST, aspartate aminotransferase; NA, not applicable.