Fig. 4.

Each row shows the perfusion maps and volume of distribution maps for a [¹¹C]PIB, b [¹⁸F]FE-PE2I, c 2-[¹⁸F]FDG and d [¹⁸F]FET for four different patients. Patient (a) had Alzheimer’s disease and pronounced beta-amyloid accumulation, and the CBF maps show typical parieto-temporal perfusion reduction (left-sided). Patient (b) was eventually diagnosed with major depression, and the CBF and volume of distribution maps were normal. Patient (c) had lung cancer with metastasis, but PET/CT of the brain did not disclose CNS involvement. Patient (d) had previously undergone surgery for brain cancer (glioblastoma), and the CBF maps show CBF reduction/no perfusion corresponding to the resection cavity, and the volume of distribution map shows abnormal frontal subcortical FET uptake, suggesting tumour recurrence. All images are shown in native orientation to avoid interpolation artefacts