Table 3.
Tikhonov method
| Radiopharmaceutical | Number of subjects/ROIs | Mean CBF ± SD (mL/min/100 mL) | Mean E ± SD | Mean K1 ± SD (mL/min/100 mL) | Mean vd ± SD (mL/100 mL) |
|---|---|---|---|---|---|
| [15O]H2O rest | 5/5 | 69 ± 19 | 0.94 ± 0.06 | - | 90 ± 5.6 |
| [15O]H2O acetazolamide | 5/5 | 115 ± 31 | 0.96 ± 0.04 | - | 92 ± 6.9 |
| [18F]FE-PE2I | 5/5 | 58 ± 15 | 0.78 ± 0.08 | 45 ± 16 | 383 ± 98 |
| [11C]PiB | 5/5 | 50 ± 7 | 0.62 ± 0.08 | 31 ± 8 | 288 ± 90 |
| [18F]FDG | 5/5 | 37 ± 13 | 0.19 ± 0.05 | 5.5 ± 1.2 | - |
| [18F]FET | 5/5 | 53 ± 16 | 0.032 ± 0.008 | 1.7 ± 0.2 | 48 ± 9 |
CBF cerebral blood flow, E extraction fraction, K1 unidirectional influx constant, vd volume of distribution