Table 9.
Comparison of outcomes by disease severity
| Instrument/domain | Mild MGa | Moderate MGa | Severe MGa | General population | P value for differences between MG categories |
|---|---|---|---|---|---|
| Breathing/Dyspnea | N = 132 | N = 124 | N = 62 | N = 126 | N = 318 |
| PROMIS-Dyspnea: General shortness of breath, mean (SD) | 1.9 (2.3) | 3.2 (2.4) | 4.9 (2.2) | 0.0 (0.7) | < 0.0001 |
| Fatigue | N = 133 | N = 125 | N = 60 | N = 2576 | N = 318 |
| FACIT-Fatigue scale, mean (SD) | 35.5 (10.1) | 26.9 (9.8) | 19.2 (8.7) | 43.5 (8.3) | < 0.0001 |
| Sleep disturbance | N = 134 | N = 125 | N = 60 | N = 319 | |
| PROMIS-Sleep Disturbance, mean (SD) | 51.2 (7.9) | 54.2 (7.6) | 57.2 (7.6) | 50.0 (10.0) | < 0.0001 |
| HADS-Anxiety | N = 443 | N = 442 | N = 215 | N = 9000 | N = 1100 |
| Normal | 2.7% | 8.8% | 7.9% | 63.6% | < 0.0001 |
| Mild | 17.4% | 26.7% | 28.8% | 16.1% | |
| Moderate | 51.0% | 45.0% | 47.4% | 10.9% | |
| Severe | 28.9% | 19.5% | 15.8% | 9.4% | |
| Score, mean (SD) | 12.1 (2.2) | 11.2 (2.5) | 11.1 (2.3) | 6.4 (4.6) | < 0.0001 |
| HADS-Depression | N = 443 | N = 442 | N = 215 | N = 9000 | N = 1100 |
| Normal | 17.4% | 27.4% | 30.7% | 84.0% | 0.043 |
| Mild | 65.5% | 56.6% | 43.7% | 9.2% | |
| Moderate | 16.3% | 13.8% | 24.2% | 4.2% | |
| Severe | 0.9% | 2.3% | 1.4% | 2.7% | |
| Score, mean (SD) | 9.1 (1.7) | 8.7 (2.0) | 8.9 (2.3) | 5 (4.1) | 0.020 |
| HUI-3: pain/discomfort | N = 222 | N = 194 | N = 104 | N = 9000 | N = 520 |
| Free of pain and discomfort | 26.1% | 9.3% | 3.9% | 45.0% | < 0.0001 |
| Mild to moderate pain or discomfort that prevented no activities | 45.1% | 26.3% | 13.5% | 38.2% | |
| Moderate pain or discomfort that prevented some activities | 21.6% | 49.5% | 43.3% | 11.1% | |
| Moderate to severe pain or discomfort that prevented some activities | 6.3% | 11.9% | 23.1% | 4.1% | |
| Severe pain or discomfort that prevented most activities | 0.9% | 3.1% | 16.4% | 1.7% | |
| Mean (SD) | 2.1 (0.9) | 2.7 (0.9) | 3.4 (1.0) | 1.8 (0.9) | < 0.0001 |
| I am bothered by limitations in performing my work (including work at home) | N = 456 | N = 445 | N = 218 | N = 9000 | N = 1119 |
| Not at all | 39.0% | 8.1% | 3.2% | 75.1% | < 0.0001 |
| Somewhat | 47.2% | 43.8% | 28.4% | 18.1% | |
| Very much | 13.8% | 48.1% | 68.4% | 6.9% | |
| Score, mean (SD) | 0.8 (0.7) | 1.4 (0.6) | 1.7 (0.5) | 0.3 (0.6) | < 0.0001 |
| I have lost some personal independence (e.g., driving, shopping, running errands) | N = 456 | N = 445 | N = 218 | N = 9000 | N = 1119 |
| Not at all | 66.0% | 28.5% | 11.0% | 83.6% | < 0.0001 |
| Somewhat | 28.3% | 44.5% | 34.9% | 11.6% | |
| Very much | 5.7% | 27.0% | 54.1% | 4.8% | |
| Score mean (SD) | 0.4 (0.6) | 1.0 (0.8) | 1.4 (0.7) | 0.3 (0.6) | < 0.0001 |
aMild MG, MG-ADL total score 0–4; moderate MG, MG-ADL total score 5–9; severe MG, MG-ADL total score ≥ 10