This study investigated the burden of myasthenia gravis (MG) regarding breathing, fatigue, sleep, pain/discomfort, mental health, and usual activities, and the effect of disease severity.

Validated patient-reported outcome measures were utilized to collect data from both patients with MG and the general population.

Patients with MG experienced significantly more breathing problems, fatigue, sleep disturbances, mental health issues, pain/discomfort, and difficulties in performing usual activities compared to the general population.

The health-related quality of life of patients with MG worsened with increased disease severity, except for mental health, where anxiety was significantly higher across all disease severities.

These findings emphasize the need for a patient-centered approach to MG treatment, addressing not only physical symptoms but also mental health aspects to improve the overall well-being of patients.