TABLE 2.
ROC curve analysis of IFN-γ ELISpot for distinguishing between CMV infection and no CMV infection.
| IFN-γ ELISpot cutoff value (SFUs/2.5×105 PBMCs) | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | Accuracy (%) |
|---|---|---|---|---|---|
| 234 | 50 | 75 | 59 | 67 | 65 |
| 240 | 50 | 78 | 62 | 68 | 66 |
| 244 | 50 | 81 | 66 | 69 | 68 |
| 255 | 48 | 81 | 65 | 68 | 67 |
Abbreviations: ROC, receiver operating characteristic; IFN-γ ELISpot, enzyme-linked immunosorbent spot assay for interferon-gamma; CMV, cytomegalovirus; SFUs, spot-forming units; PBMCs, peripheral blood mononuclear cells.
Area under the ROC curve = 0.65 (95% confidence interval 0.53–0.77).