TABLE 4.
Univariable and multivariable Cox proportional hazards model analyses of clinical and immunological factors associated with CMV reactivation after kidney transplantation.
| Factors | Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | p-value | HR | (95% CI) | p-value | |
| Female sex | 0.87 | (0.44–1.72) | 0.697 | |||
| Age | 1.03 | (1.00–1.06) | 0.095 | 1.00 | (0.97–1.04) | 0.830 |
| BMI | 1.06 | (0.97–1.16) | 0.171 | |||
| Hypertension | 2.42 | (0.74–7.92) | 0.143 | |||
| Diabetes mellitus | 1.38 | (0.53–3.56) | 0.505 | |||
| Hyperparathyroidism | 1.12 | (0.55–2.29) | 0.753 | |||
| DDKT | 2.09 | (0.87–5.05) | 0.099 | 1.65 | (0.64–4.25) | 0.303 |
| Re-transplantation | 0.98 | (0.24–4.09) | 0.979 | |||
| HLA mismatch | 0.99 | (0.76–1.28) | 0.923 | |||
| PRA | 1.02 | (1.01–1.03) | 0.001 | 1.01 | (0.99–1.02) | 0.538 |
| ATG induction therapy | 3.04 | (1.53–6.06) | 0.002 | 1.65 | (0.42–6.53) | 0.472 |
| ALC at 1 month post-transplant ≤500 cells/mm3 | 1.93 | (0.84–4.43) | 0.119 | |||
| IFN-γ ELISpot at 1 month post-transplant <250 SFUs/2.5 × 105 PBMCs | 3.30 | (1.36–8.03) | 0.008 | 2.83 | (1.12–7.13) | 0.027 |
Abbreviations: HR, hazard ratio; CI, confidence interval; BMI, body mass index; DDKT, deceased-donor kidney transplantation; HLA, human leukocyte antigen; PRA, panel-reactive antibody; ATG, anti-thymocyte globulin; ALC, absolute lymphocyte count; IFN-γ ELISpot, enzyme-linked immunosorbent spot assay for interferon-gamma; SFUs, spot-forming units; PBMCs, peripheral blood mononuclear cells.