Table 5.

The clinical presentation in vitiligo patients with T/T and T/C genotypes

Patient group	Genotyping			Fisher exact test	P-value
		T/T N = 4	T/C N = 46
Gender	Male	2 (50.0%)	18 (39.1%)	0.181	0.670
	Female	2 (50.0%)	28 (60.9%)
Age (years)	Mean ± SD	14.75 ± 4.99	24.26 ± 14.8	Z = 1.077	0.281
	Median (25th–75th)	14.50 (10.25–19.50)	18 (11.75–33.25)
BMI (Kg/m2)	Mean ± SD	31.75 ± 6.13	30.76 ± 4.28	t = 0.054	0.957
	Median (25th–75th )	32 (26–37.25)	32 (26.75–34)
Onset	Sudden	2(50.0%)	20(43.5%)	0.064	0.801
	Gradual	2(50.0%)	26(56.5%)
Course	Stationary	2(50.0%)	24(52.2%)	0.460	0.795
	Progressive	2(50.0%)	18(39.1%)
	Regressive	0(0.0%)	4(8.7%)
Family history	Absent	2(50.0%)	40(87.0%)	3.740	0.053
	Present	2(50.0%)	6(13.0%)
Leukotrichia	Yes	0(0.0%)	7(15.2%)	0.708	0.400
	No	4(100.0%)	39(84.8%)
Duration	Mean ± SD	32.50 ± 18.78	32.22 ± 35.25	Z = 0.398	0.691
	Median (25th–75th )	36 (13.5–48)	24 (12–48)
Age of onset	Mean ± SD	12.25 ± 6.65	21.63 ± 13.3	Z = 1.469	0.142
	Median (25th–75th )	12.5 (6.25–18)	18 (10–30.25)
Previous treatment	Yes	4 (100%)	44 (95.7%)	0.181	0.670
	No	0 (0%)	2 (4.3%)
Response to treatment	Improved	3 (75.0%)	36 (78.3%)	0.023	0.880
	Not improved	1 (25.0%)	10 (21.7%)
VIDA score	Mean ± SD	0.50 ± 1	2.09 ± 1.029	Z = 2.504	0.012
	Median (25th–75th )	0 (0–1)	2 (1–3)
VASI score	Mean ± SD	3.38 ± 0.64	3.63 ± 1.13	t = 0.197	0.844
	Median (25th–75th )	3.3 (2.85–4)	3.5 (2.5–4.55)
RQ of circadian gene	Mean ± SD	0.41 ± 0.284	4.018 ± 3.506	3.111	0.002
	Median (25th–75th )	0.279 (0.25–0.7)	2.185 (1.26–6.92)

Z (Mann–Whitney test), t (independent sample t test)