Table 2.
Patient self-reported measures of health-related quality of life for individuals who initiated adalimumab product as the first advanced therapy
| ABP 501 initiators | RP initiators | |
|---|---|---|
| Patient-reported treatment satisfaction, n (%) | ||
| n | 90 | 73 |
| Satisfied | 86 (95.6) | 70 (95.9) |
| Dissatisfied | 4 (4.4) | 3 (4.1) |
| EQ-5D-5L | ||
| n | 88 | 73 |
| EQ VAS, mean (SD) | 84.0 (9.9) | 79.7 (14.3) |
| EQ-5D-5L German tariff, mean (SD) | 0.96 (0.06) | 0.91 (0.12) |
| EQ-5D-5L domain: mobility, n (%) | ||
| I have no problems in walking about | 84 (95.5) | 64 (87.7) |
| I have slight problems in walking about | 4 (4.5) | 8 (11.0) |
| I have moderate problems in walking about | 0 (0.0) | 1 (1.4) |
| I have severe problems in walking about | 0 (0.0) | 0 (0.0) |
| I am unable to walk | 0 (0.0) | 0 (0.0) |
| EQ-5D-5L domain: self-care, n (%) | ||
| I have no problems washing or dressing myself | 86 (97.7) | 64 (87.7) |
| I have slight problems washing or dressing myself | 2 (2.3) | 8 (11.0) |
| I have moderate problems washing or dressing myself | 0 (0.0) | 1 (1.4) |
| I have severe problems washing or dressing myself | 0 (0.0) | 0 (0.0) |
| I am unable to wash or dress myself | 0 (0.0) | 0 (0.0) |
| EQ-5D-5L domain: usual activities, n (%) | ||
| I have no problems doing my usual activities | 79 (89.8) | 63 (86.3) |
| I have slight problems doing my usual activities | 9 (10.2) | 8 (11.0) |
| I have moderate problems doing my usual activities | 0 (0.0) | 1 (1.4) |
| I have severe problems doing my usual activities | 0 (0.0) | 1 (1.4) |
| I am unable to do my usual activities | 0 (0.0) | 0 (0.0) |
| EQ-5D-5L domain: pain/discomfort, n (%) | ||
| I have no pain or discomfort | 64 (72.7) | 28 (38.4) |
| I have slight pain or discomfort | 20 (22.7) | 34 (46.6) |
| I have moderate pain or discomfort | 4 (4.5) | 10 (13.7) |
| I have severe pain or discomfort | 0 (0.0) | 0 (0.0) |
| I have extreme pain or discomfort | 0 (0.0) | 1 (1.4) |
| EQ-5D-5L domain: anxiety/depression, n (%) | ||
| I am not anxious or depressed | 54 (61.4) | 40 (54.8) |
| I am slightly anxious or depressed | 27 (30.7) | 24 (32.9) |
| I am moderately anxious or depressed | 7 (8.0) | 7 (9.6) |
| I am severely anxious or depressed | 0 (0.0) | 2 (2.7) |
| I am extremely anxious or depressed | 0 (0.0) | 0 (0.0) |
| SIBDQ | ||
| Total score, n | 88 | 71 |
| Total score, mean (SD) | 56.4 (9.5) | 53.3 (10.9) |
| Bowel symptoms, n | 90 | 73 |
| Mean (SD) | 5.5 (1.0) | 5.1 (1.2) |
| Systemic symptoms, n | 89 | 71 |
| Mean (SD) | 5.7 (1.0) | 5.4 (1.2) |
| Emotional function, n | 90 | 73 |
| Mean (SD) | 5.5 (1.1) | 5.3 (1.2) |
| Social function, n | 88 | 71 |
| Mean (SD) | 5.9 (1.0) | 5.7 (1.2) |
| WPAI | ||
| Overall work impairmenta, n | 48 | 27 |
| Mean, % (SD) | 14.4 (14.7) | 18.1 (18.1) |
| Absenteeisma, n | 48 | 28 |
| Mean, % (SD) | 3.3 (10.7) | 1.1 (3.7) |
| Presenteeisma, n | 53 | 34 |
| Mean, % (SD) | 11.3 (11.4) | 16.8 (15.7) |
| Activity impairment, n | 89 | 72 |
| Mean, % (SD) | 17.8 (17.4) | 20.1 (16.6) |
ABP 501 adalimumab biosimilar, EQ-5D-5L EuroQol-5 Dimension-5 Level, EQ VAS EuroQol visual analogue scale, RP reference product, SD standard deviation, SIBDQ Short Inflammatory Bowel Disease Questionnaire, WPAI Work Productivity and Activity Impairment
aExcludes non-working patients