. 2024 Jan 5;4:1233293. doi: 10.3389/fpain.2023.1233293

Table 3.

TCM groups differed on patient reported outcomes.

Patient-reported outcomes	Score name (value range)	TCM#1 (Equal) (Mean ± SD)	TCM#2 (Deficiency) (Mean ± SD)	TCM#3 (Stagnation) (Mean ± SD)	Healthy (Mean ± SD)
PainDETECT	Total score (7–47)	18.92 ± 3.825^****	18.25 ± 8.095^****	22.47 ± 9.172^****	7.273 ± 0.8013
PROMIS-29	Pain intensity (0–10)	3.583 ± 2.314^****	5.6 ± 1.639^****^,^#	5.75 ± 1.88^****^,^##	0.5000 ± 1.244
	Pain interference (4–20)	11.50 ± 5.072^****	16.63 ± 5.830^****^,^##	17.27 ± 3.369^****^,^##	4.781 ± 1.791
	Physical function (4–20)	6.417 ± 1.975	8.438 ± 3.949^***	10.00 ± 4.536^****^,^#	4.333 ± 1.407
	Satisfaction with social role (4–20)	14.42 ± 5.368	7.875 ± 3.757^****^,^###	9.933 ± 4.574^****^,^#	17.50 ± 3.556
Fibromyalgia survey questionnaire	Widespread pain index (0–19)	4.667 ± 4.228^**	7.563 ± 4.066^****	6.267 ± 4.496^****	0.6061 ± 1.391
	Symptom severity score (0–12)	2.917 ± 1.832	5.313 ± 3.516^****	6.667 ± 2.637^****^,^##	1.606 ± 1.999
	Total score (0–31)	7.583 ± 5.632^*	12.88 ± 6.879^****^,^#	12.67 ± 5.367^****^,^#	2.212 ± 3.090
Pittsburgh sleep quality index (PSQI)	Global PSQI Index	12.17 ± 8.032	20.73 ± 9.293^***^,^#	20.80 ± 8.046^***^,^#	10.91 ± 6.760
Multi-dimensional fatigue inventory (MFI)	Total MFI score (0–100)	45.58 ± 9.395	56.00 ± 19.73^*	61.60 ± 15.29^***^,^#	41.91 ± 13.46
Hospital anxiety and depression scale	Anxiety score (0–21)	4.250 ± 2.417	6.250 ± 3.924^*	8.714 ± 5.413^****^,^#	2.719 ± 2.679
Hospital anxiety and depression scale	Depression score (0–21)	2.833 ± 2.038	5.250 ± 3.697^**	6.714 ± 3.750^****^,^##	1.938 ± 1.795

Patient reported outcomes in related with pain (intensity and interference), neuropathic and nociplastic pain Syndromes, physical function, sleep, and fatigue were assessed with PROMISE-29, PainDETECT, Fibromyalgia Survey Questionnaires, the Pittsburgh sleep quality index, multi-dimensional fatigue inventory, as well as Hospital anxiety and depression scale. Patients with SCD reported INCREASED pain, physiological and psychological dysfunction as compared with HCs. The stagnation and deficiency groups displayed worse outcomes than the Equal group.

p < 0.05 compared with healthy.

^**

p < 0.01 compared with healthy.

^***

p < 0.001 compared with healthy.

^****

p < 0.0001 compared with healthy.

^{^#}

p < 0.05 compared with equal.

^{^##}

p < 0.01 compared with equal.

^{^###}

p < 0.001 compared with equal.