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. 2024 Jan 5;13:1276771. doi: 10.3389/fonc.2023.1276771

Table 2.

Basic characteristics of research.

study type regions treatment regiments
group1 sample group2 sample group3 sample group4 sample
Lertkhachonsuk A 2009 (10) RCT Thailand 1 22 2 27
Lee YJ 2017 (11) retrospective study Korea 2 53 3 18 1 5
Matsui H 1998 (12) retrospective study Japan 4 192 5 126 1 46 2 36
Baptista AM 2012 (13) prospective study Brazil 2 20 1 20 1 20
Gilani MM 2005 (14) RCT Iran 3 18 6 28
Mu X 2018 (15) retrospective study China 3 34 1 26
Mousavi A 2012 (16) RCT Iran 3 50 4 25
Shahbazian N 2014 (17) RCT Iran 3 15 6 15
Korkmaz V 2022 (18) retrospective study Turkey 2 53 6 20
Maestá I 2018 (19) retrospective study Brazil 2 151 6 174
Kang HL 2019 (20) RCT China 1 49 4 59
Yarandi F 2016 (21) RCT USA 4 32 3 30
Schorge JO 2003 (22) prospective study USA 2 5 4 20 6 7
Osborne RJ 2011 (23) RCT Canada 6 107 3 109
Yarandi F 2008 (24) RCT Iran 6 81 3 50
Hoskins PJ 2020 (25) retrospective study Canada 3 100 6 97
Abrão RA 2008 (26) retrospective study Brazil 1 42 4 42
Uberti EMH 2015 (27) retrospective study Brazil 2 115 3 79
Roberts JP 1996 (28) retrospective study USA 1 4 4 61
Kang WD 2010 (29) retrospective study Korea 2 59 6 48
Matsui H 2005 (30) retrospective study Japan 2 24 4 132 5 90 1 25
Fülöp V 2021 (31) retrospective study Hungary 2 304 1 109
Xu J 2022 (32) retrospective study China 1 88 4 122
Anfinan N.M 2020 (33) RCT Jeddah 2 26 6 34

group: 1. ACT-D: 10 Kg/kg per day intravenously for 5 days, every 2 weeks, 2. MTX: 1 mg/kg per day on days 1, 3, 5, and 7, alternating with intramuscular folinic acid 0.1 mg/kg per day on days 2, 4, 6, and 8, every two weeks, 3. ACT-D: pulse actinomycin-D (1.25 mg/m2 ) once every 14 days with a maximum dose of 2 mg, 4. MTX: 0.4mg/kg 5 days, 5. VP-16: 2.0mg/kg 5 days, 6. MTX: 30 -50 mg/m2 weekly.