TABLE 1.

List of main miRNAs regulating ion channel expression/function in midbrain dopaminergic neurons, differentiating precursor cells and cell lines used to model PD.

Type of miRNA	Target ion channel(s)	Change of expression/function	Cell type/brain area	Main effect	References
miR-128	NaV, CaV, GABA transporter and high affinity glutamate receptors	↓Expression	Striatal neurons	Motor behaviour (mice)	Tan et al., 2013
miR-34b/c	NaV, KV	↑Expression	Fibroblast differentiation to iDA	Increase excitability	De Gregorio et al., 2018
miR-34a	HERG K	↓Expression	SH-SY5Y cell line	Rotenone sensitivity	Lin et al., 2011
miR-218	KCA	↑Function	Native DA neurons	Excitability/DA release	Pulcrano et al., 2023
miR-218	NaV, KV, HCN	↑Expression	Astrocyte differentiation to iDA	Excitability	Rivetti di Val Cervo et al., 2017
miR-324	Vdac1	↓Expression	Striatal neurons	Ca2+-regulation of signaling pathways	Liu et al., 2019
miR-625	TRPM2	↑Expression	SH-SY5Y cell line	Ca2+ influx	Ding et al., 2019
miR-22	TRPM7	↓Expression	PC12 cell line	Ca2+ influx	Yang et al., 2016
miR-133b miR-181a	KATP	↑Expression	NSC differentiation to DA neurons	Cell survival and differentiation	Zhou et al., 2018
miR-96	CACNG5	↓Expression	Native DA neurons	Cell apoptosis	Dong et al., 2018