Table 2.
Previously identified genome-wide significant variants from GWAS of cognitive decline.
| Global cognitive functioning | Sherva et al. [11] (N = 303) Alzheimer’s disease assessment scale in AD patients |
TOMMORROW Trial (N = 2515) Global cognition in cognitively normal individuals |
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|---|---|---|---|---|---|---|---|---|---|---|
| Intercept | Age at baseline | Slope 1 | Slope 2 | |||||||
| N | rsID | Beta (p-value) | Effect allele | Population | Phenotypic measures | Beta (p-value) | Beta (p-value) | Beta (p-value) | Beta (p-value) | |
| In global cognition | 303 | rs11023139 | 0.31 (7.00e−11) | ? / A | Clinical—Alzheimer’s disease patients | Alzheimer’s Disease Assessment Scale-cognitive subscale. Memory, language, praxis, attention etc. | 0.10 (0.06) | −0.01 (0.05) | −0.22 (0.28) | 0.22 (0.03) |
| Executive functioning |
Wendel et al. [10] (N = 1338) A genome-wide association study of the longitudinal course of executive functions |
TOMMORROW Trial (N = 2515) Global cognition in cognitively normal individuals |
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| N | rsID | beta (p-value) | Effect allele | Population | Phenotypic measures | Beta (p-value) | Beta (p-value) | Beta (p-value) | Beta (p-value) | |
| In global cognition | 1338 | rs150547358 | 1.16 (7.20e−10) | C/- | Clinical - affective-to-psychotic spectrum; and controls | Set-shifting (Trail-Making Test, part B (TMT-B)) and updating (Verbal Digit Span backwards) | – | – | – | – |
| In EF domain | 1338 | rs150547358 | 1.16 (7.20e−10) | C / C | 0.67 (0.38) | −0.01 (0.44) | 0.21 (0.75) | −0.43 (0.07) | ||
| Attention domain |
Kamboh et al. [9], (N = 1145) Population-based genome-wide association study of cognitive decline in older adults free of dementia: Identification of a novel locus for the attention domain |
TOMMORROW Trial (N = 2515) Global cognition in cognitively normal individuals |
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| N | rsID | Beta (p-value) | Effect allele | Population | Phenotypic measures | Beta (p-value) | Beta (p-value) | Beta (p-value) | Beta (p-value) | |
| In global cognition | 1145 | rs9535753 | 0.28 (3.37e−08) | C/C | General | Trail-making Test A | −0.04 (0.13) | 0.01 (0.06) | 0.12 (0.26) | −0.02 (0.72) |
| In attention domain | 1145 | rs9535753 | 0.28 (3.37e−08) | C/C | General | Trail-making Test A | 0.14 (0.59) | −0.002 (0.62) | −0.16 (0.41) | −0.06 (0.56) |