Table 2.

Univariable and multivariable analysis of CO level >11 ppm and 1-year death and MAE.

Panel A: 1-year death	HR	95% CI	p-value
Univariable analysisa	6.1	2.5–14.6	<0.001
Multivariable analysis
Model 1	5.9	2.4–14.4	<0.001
Model 2	6.1	2.5–14.8	<0.001
Model 3	6.6	2.6–16.5	<0.001
Propensity-matched population analysis	7.5	1.7–32.8	<0.001

Panel B: Intra-hospital MAE (initial hospitalisation)	OR	95% CI	p-value
Univariable analysisa	11.4	4.5–28.5	<0.001
Multivariable analysis
Model 1	15.7	5.6–44.6	<0.001
Model 2	10.7	4.1–28.0	<0.001
Model 3	20.6	6.4–66.1	<0.001

Model 1: age, sex, main admission diagnosis, diabetes, history of cardiovascular disease before hospitalisation, known chronic kidney disease with a glomerular filtration rate <60 mL/min (yes/no), and history of cancer (yes/no).

Model 2: age, sex, main admission diagnosis, systolic blood pressure, Killip class, and heart rate.

Model 3: age, sex, main admission diagnosis, BMI, previous COPD or asthma (yes/no), oxygen flow rate at admission, oxygen saturation at admission, haemoglobin level at admission, and intravenous diuretic treatment (yes/no).

Intra hospital MAE: Intra hospital major adverse events (initial hospitalisation): death, resuscitated cardiac arrest and cardiogenic shock.

Abbreviations: HR: Hazard ratio; OR: Odds ratio; CI: confidence interval; CO: carbon monoxide; BMI: body mass index; COPD: chronic obstructive pulmonary disease; MAE: in-hospital major adverse event.

Panel A: HR (95% CI) of CO level >11 ppm and, 1-year death in univariable and multivariable analysis with model 1, 2 and, 3 and, propensity-matched population 1:1.

Panel B: OR (95% CI) of CO level >11 ppm and intra hospital MAE (initial hospitalisation) in univariable and, multivariable analysis with model 1, 2 and, 3.

^aAdjusted on age and sex.