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. 2023 Dec 26;15(12):6928–6945. doi: 10.21037/jtd-23-1746

Figure 4.

Figure 4

Genomic alterations between the DDR-activated and DDR-suppressed subgroups. (A) Tumor median mutation burden of 3.39/MB. (B) The TMB was significantly higher in cluster 2 (n=283) compared to cluster 1 (n=225) (P<0.01). (C) Mutual exclusion/co-occurrence analysis of mutations in each cohort. (D) Landscape of mutation profiles in the LUAD samples. The waterfall plot displays the mutation information for each gene in each sample. The data were analyzed based on TCGA data portal. ***, P<0.01. TMB, tumor mutational burden; MB, megabase; OR, odds ratio; CI, confidence interval; DDR, DNA damage repair; LUAD, lung adenocarcinoma; TCGA, The Cancer Genome Atlas.