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. 2023 Nov 27;11(3):2303555. doi: 10.1002/advs.202303555

Figure 5.

Figure 5

RIPK3–/– alleviated anemia in Abin1Q478H/Q478H mice via necroptosis‐independent function a) Peripheral blood analysis of 10‐month‐old Abin1Q478H/Q478H and Abin1Q478H/Q478HRipk3–/– mice, including red blood cell (RBC) counts and hemoglobin (HGB) levels. (n ≥ 16 mice/group). b) Different sizes and weights of the spleens of the 10‐month‐old Abin1Q478H/Q478H and Abin1Q478H/Q478HRipk3–/– mice. (n ≥ 12 mice/group) c) Hematoxylin and eosin staining of spleen, liver, and bone marrow samples. Representative of at least three 10‐month‐old mice per group. d) Quantification of the myeloid (CD11b+ and Gr1+) frequencies of the 10‐month‐old Abin1Q478H/Q478H and Abin1Q478H/Q478HRipk3–/– mice. (n ≥ 13 mice/group) e) Peripheral blood analysis of 10‐month‐old wild‐type (WT), Abin1Q478H/Q478H , Abin1Q478H/Q478HRipk3–/– , Abin1Q478H/Q478HRipk1K45A/K45A , and Abin1Q478H/Q478H Mlkl–/– mice, including red blood cell (RBC) counts and hemoglobin (HGB) levels. (n ≥ 11 mice/group) The panel data were analyzed using the two‐tailed unpaired Student t‐test, and statistical significance was indicated as follows: **** for P < 0.0001, *** for P < 0.001, ** for P < 0.01, and * for P < 0.05.