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. 2023 Nov 29;11(3):2303894. doi: 10.1002/advs.202303894

Figure 3.

Figure 3

Blockage of taurine export/import by TauT knockout restores sensitivity of ferroptosis in PCa cells. A) Taurine level in M2‐NC lCM and M2‐KO lCM. B) Cell viability of PCa cells after incubated with M2‐NC lCM or M2‐KO lCM for 24 h following with the RSL3 treatment for another 24 h. C–F) Taurine level (C), cell viability (D), Lipid peroxidation level (E), and MDA level (F) in TauT knockout or control PCa cells with taurine (100 µm) treatment. G,H) Harvested xenografts (G) and tumor weight measurement (H) after inoculation of PCa cells with/without TauT knockout following with the RSL3 or DMSO treatment. (Scale bar = 1 cm, n = 5.) I) H&E and IHC staining in harvested xenografts (Scale bar = 100 µm). Each experiment was performed in triplicate and independently repeated three times. (Two‐tailed Student's t‐test was used for the statistical analysis: *, p < 0.05; **, p < 0.01; ***, p < 0.001. Data are presented as means ± SD, n = 3).