TABLE 1.
Maternal baseline characteristics and offspring characteristics at birth, stratified by treatment group and maternal genotype of SNP rs174602.1
| Treatment group |
Maternal Genotype of SNP rs174602 |
||||
|---|---|---|---|---|---|
| Placebo | DHA | CC | TC | TT | |
| N = 154 | N = 160 | N = 127 | N = 143 | N = 44 | |
| Maternal factors, enrollment | |||||
| Age, y | 26.6 (4.61) | 27.4 (5.18) | 27.0 (4.81) | 27.2 (5.01) | 26.8 (5.02) |
| BMI, kg/m2 | 26.3 (4.10) | 26.6 (4.13) | 26.3 (4.12) | 26.4 (3.92) | 27.1 (4.65) |
| Height, cm | 156 (5.54) | 155 (5.57) | 155 (5.66) | 155 (5.46) | 157 (5.54) |
| First pregnancy, % | 53 (34.4%) | 45 (28.1%) | 37 (29.1%) | 50 (35.0%) | 11 (25.0%) |
| SES Score2 | 0.13 (1.05) | 0.13 (0.89) | 0.01 (1.03) | 0.13 (0.94) | 0.46 (0.81) |
| Schooling, y | 12.3 (3.39) | 11.9 (3.45) | 11.6 (3.56) | 12.3 (3.40) | 12.6 (2.96) |
| Dietary intake at enrollment, g/d | |||||
| ALA | 1.76 (1.00) | 1.79 (1.08) | 1.76 (1.04) | 1.80 (1.00) | 1.73 (1.18) |
| DHA | 0.08 (0.07) | 0.08 (0.08) | 0.08 (0.08) | 0.08 (0.06) | 0.10 (0.11) |
| LA | 19.3 (7.76) | 19.7 (8.64) | 19.4 (7.78) | 19.7 (7.79) | 19.2 (10.6) |
| EPA | 0.03 (0.04) | 0.03 (0.04) | 0.03 (0.04) | 0.03 (0.03) | 0.04 (0.06) |
| AA | 0.15 (0.07) | 0.16 (0.09) | 0.15 (0.06) | 0.16 (0.09) | 0.15 (0.06) |
| Compliance to intervention, % | 95.0 (5.00) | 95.7 (4.99) | 95.1 (5.55) | 95.8 (4.53) | 94.6 (4.76) |
| Offspring factors, birth | |||||
| Sex | |||||
| Male | 81 (52.6%) | 93 (58.1%) | 69 (54.3%) | 80 (55.9%) | 25 (56.8%) |
| Female | 73 (47.4%) | 67 (41.9%) | 58 (45.7%) | 63 (44.1%) | 19 (43.2%) |
| Birth weight, g | 3220 (490) | 3230 (449) | 3229 (532) | 3220 (440) | 3231 (367) |
| Gestational age, wk | 39.0 (1.66) | 39.1 (1.91) | 38.8 (1.97) | 39.1 (1.70) | 39.4 (1.44) |
| Infant feeding practices, 3 mo, % | |||||
| Exclusively fed human milk | 23 (16.2%) | 17 (12.0%) | 18 (15.8%) | 15 (11.6%) | 7 (17.1%) |
| Predominantly fed human milk | 20 (14.1%) | 15 (10.6%) | 11 (9.65%) | 17 (13.2%) | 7 (17.1%) |
| Partially fed human milk | 75 (52.8%) | 80 (56.3%) | 59 (51.8%) | 78 (60.5%) | 18 (43.9%) |
| Not fed human milk | 24 (16.9%) | 30 (21.1%) | 26 (22.8%) | 19 (14.7%) | 9 (22.0%) |
| Duration of human milk feeding, mo | 9.71 (7.96) | 8.84 (7.65) | 8.15 (6.86) | 10.3 (8.56) | 9.21 (7.53) |
SES, socioeconomic status score; ALA, Alpha-Linolenic Acid; LA, Linoleic Acid; AA, Arachidonic Acid.
1
Chi-square tests, t-tests, and ANOVA were used to test differences between groups. No differences by treatment group were observed. Values presented are mean (SD) unless otherwise stated.
2
Differs by maternal genotype (P < 0.05).