Table 4.
QSM region | |||||||||||||||
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| |||||||||||||||
First author (year) | N | Age | Other measure | FC | TC | PC | OC | CN | PT | GP | RN | SN | TH | HC | AM |
van Bergen et al. (2018b) | 116 | 50-95 | AP | + | + | + | + | + | + | + | + | + | |||
Chen et al. (2021b) | 150 | M = 69 | AP | + | + | + | + | − | 0 | 0 | + | + | |||
Bauer et al. (2021) | 80 | 60-86 | Deep WMH | + | + | + | + | + | + | ||||||
PV WMH | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||
van Bergen et al. (2018a) | 80 | 55-96 | Global WMH | 0 | − | − | 0 | 0 | 0 | ||||||
Chiang et al. (2022) | 32 | 50-87 | Global WMH | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
Li et al. (2021) | 44 | M = 59 | Global WMH | 0 | 0 | 0 | 0 | 0 | 0 | ||||||
Gong et al. (2015) | 42 | 25-78 | FA/M Kurtosis | 0 | + | 0 | 0 | 0 | 0 | ||||||
Yang et al. (2022) | 25 | M = 67 | Axial kurtosis | + | 0 | 0 | 0 | 0 | |||||||
Zhou et al. (2020) | 213 | 43-80 | Diffusivity index | + | + | + | + | + | + | ||||||
Zachariou et al. (2023) | 95 | 60-86 | Neurite density | − | − | ||||||||||
Garzon et al. (2017) * | 22 | M = 36 | R2* | + | + | + | + | + | + | ||||||
18 | M = 70 | ||||||||||||||
Taege et al. (2019) | 33 | M = 52 | R2* | + | + | + | + | − | |||||||
Li et al. (2014) | 191 | 1-83 | R2* | + | + | + | + | + | + | + | |||||
Quevenco et al. (2017) | 37 | 62-89 | Nodal strength | + | 0 | + | + | + | 0 | 0 | 0 | 0 | |||
Persson et al. (2020) * | 21 | M = 36 | BOLD signal | + | + | ||||||||||
15 | M = 70 | ||||||||||||||
Zachariou et al. (2020) | 55 | 61-86 | Functional conn | − | |||||||||||
Guan et al. (2019) | 35 | M = 58 | Functional conn | − | − |
Note. Age = range or mean years of age of sample.
For each study, symbols indicate positive (+), negative (−), or nonsignificant (0) associations between susceptibility and another MRI measure. Studies are sorted by the secondary MRI measure that was examined.
FC = frontal cortex; TC = temporal cortex; PC = parietal cortex; OC = occipital cortex; CN = caudate nucleus; PT = putamen; GP = globus pallidus; RN = red nucleus; SN = substantia nigra; TH = thalamus; HC = hippocampus; AM = amygdala; Aβ = amyloid beta; WMH = white matter hyperintensities; FA = fractional anisotropy; BOLD = blood oxygen level dependent; PV = periventricular; conn = connectivity.
Data presented are averaged across all participants.